Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body’s physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other metabolites. Previous studies suggested that mesenchy...

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Autores principales: Zhong, Yixiu, Zhang, Youfan, Yu, Aijiao, Zhang, Zhiwen, Deng, Zhenjun, Xiong, Kaifen, Wang, Qi, Zhang, Jianglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536244/
https://www.ncbi.nlm.nih.gov/pubmed/37781228
http://dx.doi.org/10.3389/fphys.2023.1247734
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author Zhong, Yixiu
Zhang, Youfan
Yu, Aijiao
Zhang, Zhiwen
Deng, Zhenjun
Xiong, Kaifen
Wang, Qi
Zhang, Jianglin
author_facet Zhong, Yixiu
Zhang, Youfan
Yu, Aijiao
Zhang, Zhiwen
Deng, Zhenjun
Xiong, Kaifen
Wang, Qi
Zhang, Jianglin
author_sort Zhong, Yixiu
collection PubMed
description Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body’s physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other metabolites. Previous studies suggested that mesenchymal stem cell (MSC)-derived exosomes could either suppress or support keloid and hypertrophic scar progression. Although previous research has identified the potential value of MSC-exosomes in keloid and hypertrophic scar, a comprehensive analysis of different sources of MSC-exosome in keloid and hypertrophic scar is still lacking. This review mainly discusses different insights regarding the roles of MSC-exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.
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spelling pubmed-105362442023-09-29 Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms Zhong, Yixiu Zhang, Youfan Yu, Aijiao Zhang, Zhiwen Deng, Zhenjun Xiong, Kaifen Wang, Qi Zhang, Jianglin Front Physiol Physiology Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body’s physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other metabolites. Previous studies suggested that mesenchymal stem cell (MSC)-derived exosomes could either suppress or support keloid and hypertrophic scar progression. Although previous research has identified the potential value of MSC-exosomes in keloid and hypertrophic scar, a comprehensive analysis of different sources of MSC-exosome in keloid and hypertrophic scar is still lacking. This review mainly discusses different insights regarding the roles of MSC-exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10536244/ /pubmed/37781228 http://dx.doi.org/10.3389/fphys.2023.1247734 Text en Copyright © 2023 Zhong, Zhang, Yu, Zhang, Deng, Xiong, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhong, Yixiu
Zhang, Youfan
Yu, Aijiao
Zhang, Zhiwen
Deng, Zhenjun
Xiong, Kaifen
Wang, Qi
Zhang, Jianglin
Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
title Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
title_full Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
title_fullStr Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
title_full_unstemmed Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
title_short Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
title_sort therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536244/
https://www.ncbi.nlm.nih.gov/pubmed/37781228
http://dx.doi.org/10.3389/fphys.2023.1247734
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