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Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
This intricate case report details an exceptionally rare incidence of ovarian metastasis originating from a primary lung adenocarcinoma (LUAD). The relative rarity of this metastatic pathway in medical literature indicates significant diagnostic challenges. This patient was initially found to have b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536256/ https://www.ncbi.nlm.nih.gov/pubmed/37780910 http://dx.doi.org/10.3389/fsurg.2023.1278076 |
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author | Wang, Baofeng Jia, Youjuan Wang, Jiang Zhang, Zhenjiang Ding, Yilin Lu, Hengxiao |
author_facet | Wang, Baofeng Jia, Youjuan Wang, Jiang Zhang, Zhenjiang Ding, Yilin Lu, Hengxiao |
author_sort | Wang, Baofeng |
collection | PubMed |
description | This intricate case report details an exceptionally rare incidence of ovarian metastasis originating from a primary lung adenocarcinoma (LUAD). The relative rarity of this metastatic pathway in medical literature indicates significant diagnostic challenges. This patient was initially found to have both the ovarian tumor and lung nodule and they were originally considered independent primary tumors, derived from radiological interpretations and biomarker profiling. Nevertheless, subsequent postoperative histopathological and immunohistochemical staining evaluations identified ovarian tumors as invasive adenocarcinoma metastasized from lung. The lung and ovary tumor both showed marked anaplastic lymphoma kinase gene (ALK) protein expression by immunohistochemistry. The molecular pathologic genetic testing for lung tumor also revealed ALK rearrangement positive. The complexity of this case underscores the essentiality of maintaining a high degree of diagnostic vigilance, particularly when confronting synchronous tumors. In addition, immunohistochemical staining plays an important role in diagnosing the ovarian neoplasm's metastatic nature and determining the primary site of metastatic adenocarcinoma. For lung cancer with ovary metastasis patients, the adopting an adaptable treatment approach responsive to evolving diagnostic evidence can improve the accuracy of diagnosis and avoid excessive treatment of patients. |
format | Online Article Text |
id | pubmed-10536256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105362562023-09-29 Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report Wang, Baofeng Jia, Youjuan Wang, Jiang Zhang, Zhenjiang Ding, Yilin Lu, Hengxiao Front Surg Surgery This intricate case report details an exceptionally rare incidence of ovarian metastasis originating from a primary lung adenocarcinoma (LUAD). The relative rarity of this metastatic pathway in medical literature indicates significant diagnostic challenges. This patient was initially found to have both the ovarian tumor and lung nodule and they were originally considered independent primary tumors, derived from radiological interpretations and biomarker profiling. Nevertheless, subsequent postoperative histopathological and immunohistochemical staining evaluations identified ovarian tumors as invasive adenocarcinoma metastasized from lung. The lung and ovary tumor both showed marked anaplastic lymphoma kinase gene (ALK) protein expression by immunohistochemistry. The molecular pathologic genetic testing for lung tumor also revealed ALK rearrangement positive. The complexity of this case underscores the essentiality of maintaining a high degree of diagnostic vigilance, particularly when confronting synchronous tumors. In addition, immunohistochemical staining plays an important role in diagnosing the ovarian neoplasm's metastatic nature and determining the primary site of metastatic adenocarcinoma. For lung cancer with ovary metastasis patients, the adopting an adaptable treatment approach responsive to evolving diagnostic evidence can improve the accuracy of diagnosis and avoid excessive treatment of patients. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10536256/ /pubmed/37780910 http://dx.doi.org/10.3389/fsurg.2023.1278076 Text en © 2023 Wang, Jia, Wang, Zhang, Ding and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Wang, Baofeng Jia, Youjuan Wang, Jiang Zhang, Zhenjiang Ding, Yilin Lu, Hengxiao Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report |
title | Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report |
title_full | Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report |
title_fullStr | Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report |
title_full_unstemmed | Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report |
title_short | Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report |
title_sort | rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536256/ https://www.ncbi.nlm.nih.gov/pubmed/37780910 http://dx.doi.org/10.3389/fsurg.2023.1278076 |
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