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Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report

This intricate case report details an exceptionally rare incidence of ovarian metastasis originating from a primary lung adenocarcinoma (LUAD). The relative rarity of this metastatic pathway in medical literature indicates significant diagnostic challenges. This patient was initially found to have b...

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Autores principales: Wang, Baofeng, Jia, Youjuan, Wang, Jiang, Zhang, Zhenjiang, Ding, Yilin, Lu, Hengxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536256/
https://www.ncbi.nlm.nih.gov/pubmed/37780910
http://dx.doi.org/10.3389/fsurg.2023.1278076
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author Wang, Baofeng
Jia, Youjuan
Wang, Jiang
Zhang, Zhenjiang
Ding, Yilin
Lu, Hengxiao
author_facet Wang, Baofeng
Jia, Youjuan
Wang, Jiang
Zhang, Zhenjiang
Ding, Yilin
Lu, Hengxiao
author_sort Wang, Baofeng
collection PubMed
description This intricate case report details an exceptionally rare incidence of ovarian metastasis originating from a primary lung adenocarcinoma (LUAD). The relative rarity of this metastatic pathway in medical literature indicates significant diagnostic challenges. This patient was initially found to have both the ovarian tumor and lung nodule and they were originally considered independent primary tumors, derived from radiological interpretations and biomarker profiling. Nevertheless, subsequent postoperative histopathological and immunohistochemical staining evaluations identified ovarian tumors as invasive adenocarcinoma metastasized from lung. The lung and ovary tumor both showed marked anaplastic lymphoma kinase gene (ALK) protein expression by immunohistochemistry. The molecular pathologic genetic testing for lung tumor also revealed ALK rearrangement positive. The complexity of this case underscores the essentiality of maintaining a high degree of diagnostic vigilance, particularly when confronting synchronous tumors. In addition, immunohistochemical staining plays an important role in diagnosing the ovarian neoplasm's metastatic nature and determining the primary site of metastatic adenocarcinoma. For lung cancer with ovary metastasis patients, the adopting an adaptable treatment approach responsive to evolving diagnostic evidence can improve the accuracy of diagnosis and avoid excessive treatment of patients.
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spelling pubmed-105362562023-09-29 Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report Wang, Baofeng Jia, Youjuan Wang, Jiang Zhang, Zhenjiang Ding, Yilin Lu, Hengxiao Front Surg Surgery This intricate case report details an exceptionally rare incidence of ovarian metastasis originating from a primary lung adenocarcinoma (LUAD). The relative rarity of this metastatic pathway in medical literature indicates significant diagnostic challenges. This patient was initially found to have both the ovarian tumor and lung nodule and they were originally considered independent primary tumors, derived from radiological interpretations and biomarker profiling. Nevertheless, subsequent postoperative histopathological and immunohistochemical staining evaluations identified ovarian tumors as invasive adenocarcinoma metastasized from lung. The lung and ovary tumor both showed marked anaplastic lymphoma kinase gene (ALK) protein expression by immunohistochemistry. The molecular pathologic genetic testing for lung tumor also revealed ALK rearrangement positive. The complexity of this case underscores the essentiality of maintaining a high degree of diagnostic vigilance, particularly when confronting synchronous tumors. In addition, immunohistochemical staining plays an important role in diagnosing the ovarian neoplasm's metastatic nature and determining the primary site of metastatic adenocarcinoma. For lung cancer with ovary metastasis patients, the adopting an adaptable treatment approach responsive to evolving diagnostic evidence can improve the accuracy of diagnosis and avoid excessive treatment of patients. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10536256/ /pubmed/37780910 http://dx.doi.org/10.3389/fsurg.2023.1278076 Text en © 2023 Wang, Jia, Wang, Zhang, Ding and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Wang, Baofeng
Jia, Youjuan
Wang, Jiang
Zhang, Zhenjiang
Ding, Yilin
Lu, Hengxiao
Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
title Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
title_full Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
title_fullStr Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
title_full_unstemmed Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
title_short Rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
title_sort rare giant ovarian metastasis arising from a small primary lung adenocarcinoma: a case report
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536256/
https://www.ncbi.nlm.nih.gov/pubmed/37780910
http://dx.doi.org/10.3389/fsurg.2023.1278076
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