Cargando…

Recent Advances and Innovations in the Preparation and Purification of In Vitro-Transcribed-mRNA-Based Molecules

The coronavirus disease 2019 (COVID-19) pandemic poses a disruptive impact on public health and the global economy. Fortunately, the development of COVID-19 vaccines based on in vitro-transcribed messenger RNA (IVT mRNA) has been a breakthrough in medical history, benefiting billions of people with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jingjing, Liu, Yuheng, Li, Chao, Xiao, Qin, Zhang, Dandan, Chen, Yang, Rosenecker, Joseph, Ding, Xiaoyan, Guan, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536309/ https://www.ncbi.nlm.nih.gov/pubmed/37765153 http://dx.doi.org/10.3390/pharmaceutics15092182

Ejemplares similares

Nanotechnologies in Delivery of DNA and mRNA Vaccines to the Nasal and Pulmonary Mucosa
por: Tang, Jie, et al.
Publicado: (2022)

Nebulisation of IVT mRNA Complexes for Intrapulmonary Administration
por: Johler, Sarah M., et al.
Publicado: (2015)

Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA
por: Linares-Fernández, Sergio, et al.
Publicado: (2021)

In Vitro Investigations on Optimizing and Nebulization of IVT-mRNA Formulations for Potential Pulmonary-Based Alpha-1-Antitrypsin Deficiency Treatment †
por: Guan, Shan, et al.
Publicado: (2021)

Mesoporous Silica Particle as an RNA Adsorbent for Facile Purification of In Vitro-Transcribed RNA
por: Cho, Eunbin, et al.
Publicado: (2023)

Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics
por: Kang, Diana D., et al.
Publicado: (2023)

Differential translation of mRNA isoforms transcribed with distinct sigma factors
por: McCormick, Dylan M., et al.
Publicado: (2021)

Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA
por: Vlatkovic, Irena, et al.
Publicado: (2022)

Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice
por: Zhang, Yu, et al.
Publicado: (2022)

Transcribed in synchronicity
por: LeBrasseur, Nicole
Publicado: (2003)

Recent Methods for Purification and Structure Determination of Oligonucleotides
por: Zhang, Qiulong, et al.
Publicado: (2016)

Transcribed Ultraconserved Regions in Cancer
por: Gibert, Myron K., et al.
Publicado: (2022)

Characterising the Canine Oral Microbiome by Direct Sequencing of Reverse-Transcribed rRNA Molecules
por: McDonald, James E., et al.
Publicado: (2016)

Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death
por: Ejeskär, Katarina, et al.
Publicado: (2005)

A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA
por: Baiersdörfer, Markus, et al.
Publicado: (2019)

In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
por: Parayath, N. N., et al.
Publicado: (2020)

Lateral flow immunoassay for rapid and sensitive detection of dsRNA contaminants in in vitro-transcribed mRNA products
por: Luo, Dengwang, et al.
Publicado: (2023)

Preparative Purification of Liriodendrin from Sargentodoxa cuneata by Macroporous Resin
por: Li, Di-Hua, et al.
Publicado: (2015)

Chlorophyllides: Preparation, Purification, and Application
por: Wang, Yi-Ting, et al.
Publicado: (2021)

Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases
por: Herrera-Arozamena, Clara, et al.
Publicado: (2016)

Innovative approach for transcriptomic analysis of obligate intracellular pathogen: selective capture of transcribed sequences of Ehrlichia ruminantium
por: Emboulé, Loïc, et al.
Publicado: (2009)

pseudoMap: an innovative and comprehensive resource for identification of siRNA-mediated mechanisms in human transcribed pseudogenes
por: Chan, Wen-Ling, et al.
Publicado: (2013)

A transcribed ultraconserved noncoding RNA, Uc.173, is a key molecule for the inhibition of lead-induced neuronal apoptosis
por: Nan, Aruo, et al.
Publicado: (2015)

Transcribing “silent” DNA resilences it
por: Robinson, Richard
Publicado: (2008)

Making sense of transcribing chromatin
por: Owen-Hughes, Tom, et al.
Publicado: (2012)

Identifying transcribed sequences, and beyond
por: Wellenreuther, Ruth, et al.
Publicado: (2003)

Proximity Ligation Assays for In Situ Detection of Innate Immune Activation: Focus on In Vitro-Transcribed mRNA
por: Blanchard, Emmeline L., et al.
Publicado: (2018)

Recruiting In Vitro Transcribed mRNA against Cancer Immunotherapy: A Contemporary Appraisal of the Current Landscape
por: Miliotou, Androulla N., et al.
Publicado: (2023)

In-vitro Transcribed mRNA Delivery Using PLGA/PEI Nanoparticles into Human Monocyte-derived Dendritic Cells
por: Sharifnia, Zarin, et al.
Publicado: (2019)

Rapid Delivery of Nanobodies/V(H)Hs into Living Cells via Expressing In Vitro-Transcribed mRNA
por: Zhou, Xuechen, et al.
Publicado: (2020)

Preparation of Cellulose Nanocrystals from Jujube Cores by Fractional Purification
por: Wang, Xiaorui, et al.
Publicado: (2022)

An origin of the immunogenicity of in vitro transcribed RNA
por: Mu, Xin, et al.
Publicado: (2018)

Translation of in vitro-transcribed RNA therapeutics
por: von der Haar, Tobias, et al.
Publicado: (2023)

Characterization, Preparation, and Purification of Marine Bioactive Peptides
por: Wang, Xueqin, et al.
Publicado: (2017)

Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes
por: Ono, Ryuichi, et al.
Publicado: (2015)

The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally
por: García-Molinero, Varinia, et al.
Publicado: (2018)

Safe and effective aerosolization of in vitro transcribed mRNA to the respiratory tract epithelium of horses without a transfection agent
por: Legere, Rebecca M., et al.
Publicado: (2021)

Recent Advances in Nanoporous Membranes for Water Purification
por: Wang, Zhuqing, et al.
Publicado: (2018)

Different Families of Retrotransposons and DNA Transposons Are Actively Transcribed and May Have Transposed Recently in Physcomitrium (Physcomitrella) patens
por: Vendrell-Mir, Pol, et al.
Publicado: (2020)

In Vitro-Transcribed mRNA Chimeric Antigen Receptor T Cell (IVT mRNA CAR T) Therapy in Hematologic and Solid Tumor Management: A Preclinical Update
por: Soundara Rajan, Thangavelu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4tgs01lgh3neko7bm5fa916fo0