Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue

hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (I(Kr)) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of long QT syndrome. E-4031 is a high potency hER...

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Detalles Bibliográficos
Autores principales: Helliwell, Matthew V., Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536391/
https://www.ncbi.nlm.nih.gov/pubmed/37765012
http://dx.doi.org/10.3390/ph16091204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536391/
https://www.ncbi.nlm.nih.gov/pubmed/37765012
http://dx.doi.org/10.3390/ph16091204

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