Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy

Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes, is a major cause of acquired blindness in adults. Currently, a clinical diagnosis of DR primarily relies on fundus fluorescein angiography, with a limited availability of effective biomarkers. Metabolomics, a discipline d...

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Detalles Bibliográficos
Autores principales: He, Shuling, Sun, Lvyun, Chen, Jiali, Ouyang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536395/
https://www.ncbi.nlm.nih.gov/pubmed/37755287
http://dx.doi.org/10.3390/metabo13091007
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author He, Shuling
Sun, Lvyun
Chen, Jiali
Ouyang, Yang
author_facet He, Shuling
Sun, Lvyun
Chen, Jiali
Ouyang, Yang
author_sort He, Shuling
collection PubMed
description Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes, is a major cause of acquired blindness in adults. Currently, a clinical diagnosis of DR primarily relies on fundus fluorescein angiography, with a limited availability of effective biomarkers. Metabolomics, a discipline dedicated to scrutinizing the response of various metabolites within living organisms, has shown noteworthy advancements in uncovering metabolic disorders and identifying key metabolites associated with DR in recent years. Consequently, this review aims to present the latest advancements in metabolomics techniques and comprehensively discuss the principal metabolic outcomes derived from analyzing blood, vitreous humor, aqueous humor, urine, and fecal samples.
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spelling pubmed-105363952023-09-29 Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy He, Shuling Sun, Lvyun Chen, Jiali Ouyang, Yang Metabolites Review Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes, is a major cause of acquired blindness in adults. Currently, a clinical diagnosis of DR primarily relies on fundus fluorescein angiography, with a limited availability of effective biomarkers. Metabolomics, a discipline dedicated to scrutinizing the response of various metabolites within living organisms, has shown noteworthy advancements in uncovering metabolic disorders and identifying key metabolites associated with DR in recent years. Consequently, this review aims to present the latest advancements in metabolomics techniques and comprehensively discuss the principal metabolic outcomes derived from analyzing blood, vitreous humor, aqueous humor, urine, and fecal samples. MDPI 2023-09-12 /pmc/articles/PMC10536395/ /pubmed/37755287 http://dx.doi.org/10.3390/metabo13091007 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Shuling
Sun, Lvyun
Chen, Jiali
Ouyang, Yang
Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy
title Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy
title_full Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy
title_fullStr Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy
title_full_unstemmed Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy
title_short Recent Advances and Perspectives in Relation to the Metabolomics-Based Study of Diabetic Retinopathy
title_sort recent advances and perspectives in relation to the metabolomics-based study of diabetic retinopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536395/
https://www.ncbi.nlm.nih.gov/pubmed/37755287
http://dx.doi.org/10.3390/metabo13091007
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