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Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study

Maternal vitamin D may be important for several organ systems in the offspring, including the reproductive system. In this population-based follow-up study of 12,991 Danish boys and girls born 2000–2003, we investigated if maternal intake of vitamin D supplements during pregnancy was associated with...

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Autores principales: Gaml-Sørensen, Anne, Brix, Nis, Lunddorf, Lea Lykke Harrits, Ernst, Andreas, Høyer, Birgit Bjerre, Toft, Gunnar, Henriksen, Tine Brink, Ramlau-Hansen, Cecilia Høst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536415/
https://www.ncbi.nlm.nih.gov/pubmed/37764822
http://dx.doi.org/10.3390/nu15184039
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author Gaml-Sørensen, Anne
Brix, Nis
Lunddorf, Lea Lykke Harrits
Ernst, Andreas
Høyer, Birgit Bjerre
Toft, Gunnar
Henriksen, Tine Brink
Ramlau-Hansen, Cecilia Høst
author_facet Gaml-Sørensen, Anne
Brix, Nis
Lunddorf, Lea Lykke Harrits
Ernst, Andreas
Høyer, Birgit Bjerre
Toft, Gunnar
Henriksen, Tine Brink
Ramlau-Hansen, Cecilia Høst
author_sort Gaml-Sørensen, Anne
collection PubMed
description Maternal vitamin D may be important for several organ systems in the offspring, including the reproductive system. In this population-based follow-up study of 12,991 Danish boys and girls born 2000–2003, we investigated if maternal intake of vitamin D supplements during pregnancy was associated with pubertal timing in boys and girls. Information on maternal intake of vitamin D supplements was obtained by self-report in mid-pregnancy. Self-reported information on the current status of various pubertal milestones was obtained every six months throughout puberty. Mean differences in months at attaining each pubertal milestone and an average estimate for the mean difference in attaining all pubertal milestones were estimated according to maternal intake of vitamin D supplements using multivariable interval-censored regression models. Lower maternal intake of vitamin D supplements was associated with later pubertal timing in boys. For the average estimate, boys had 0.5 months (95% CI 0.1; 0.9) later pubertal timing per 5 µg/day lower maternal vitamin D supplement intake. Maternal intake of vitamin D supplements was not associated with pubertal timing in girls. Spline plots and sensitivity analyses supported the findings. Whether the observed association with boys’ pubertal timing translates into an increased risk of disease in adulthood is unknown.
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spelling pubmed-105364152023-09-29 Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study Gaml-Sørensen, Anne Brix, Nis Lunddorf, Lea Lykke Harrits Ernst, Andreas Høyer, Birgit Bjerre Toft, Gunnar Henriksen, Tine Brink Ramlau-Hansen, Cecilia Høst Nutrients Article Maternal vitamin D may be important for several organ systems in the offspring, including the reproductive system. In this population-based follow-up study of 12,991 Danish boys and girls born 2000–2003, we investigated if maternal intake of vitamin D supplements during pregnancy was associated with pubertal timing in boys and girls. Information on maternal intake of vitamin D supplements was obtained by self-report in mid-pregnancy. Self-reported information on the current status of various pubertal milestones was obtained every six months throughout puberty. Mean differences in months at attaining each pubertal milestone and an average estimate for the mean difference in attaining all pubertal milestones were estimated according to maternal intake of vitamin D supplements using multivariable interval-censored regression models. Lower maternal intake of vitamin D supplements was associated with later pubertal timing in boys. For the average estimate, boys had 0.5 months (95% CI 0.1; 0.9) later pubertal timing per 5 µg/day lower maternal vitamin D supplement intake. Maternal intake of vitamin D supplements was not associated with pubertal timing in girls. Spline plots and sensitivity analyses supported the findings. Whether the observed association with boys’ pubertal timing translates into an increased risk of disease in adulthood is unknown. MDPI 2023-09-18 /pmc/articles/PMC10536415/ /pubmed/37764822 http://dx.doi.org/10.3390/nu15184039 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gaml-Sørensen, Anne
Brix, Nis
Lunddorf, Lea Lykke Harrits
Ernst, Andreas
Høyer, Birgit Bjerre
Toft, Gunnar
Henriksen, Tine Brink
Ramlau-Hansen, Cecilia Høst
Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study
title Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study
title_full Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study
title_fullStr Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study
title_full_unstemmed Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study
title_short Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study
title_sort maternal intake of vitamin d supplements during pregnancy and pubertal timing in children: a population-based follow-up study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536415/
https://www.ncbi.nlm.nih.gov/pubmed/37764822
http://dx.doi.org/10.3390/nu15184039
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