Rare Ring Chromosome [r(15)]: Cytogenetic Abnormality in TP53-Mutated De Novo AML-M4 Masked as Gastrointestinal Bleed With Rapidly Progressing Hyperleukocytosis and Leukostasis

TP53-mutated (TP53m) acute myeloid leukemia (AML) comprises only 5-15% of de novo AML, associated with poor survival outcomes due to its resistance to conventional therapy. Ring chromosomes, an even more rare subset of genetic anomalies, occur in only 2% of cases. We report a unique case of de novo...

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Detalles Bibliográficos
Autores principales: Kwentoh, Ifeoma, Bugayong, Maria Lorraine, Olusoji, Rahman, McPherson, Tasheka, Ahluwalia, Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536451/
https://www.ncbi.nlm.nih.gov/pubmed/37779685
http://dx.doi.org/10.7759/cureus.46119

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