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Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023

In December 2022 and January 2023, we isolated clade 2.3.4.4b H5N1 high-pathogenicity avian influenza (HPAI) viruses from six American crows (Corvus brachyrhynchos) from Prince Edward Island and a red fox (Vulpes vulpes) from Newfoundland, Canada. Using full-genome sequencing and phylogenetic analys...

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Autores principales: Alkie, Tamiru N., Byrne, Alexander M. P., Jones, Megan E. B., Mollett, Benjamin C., Bourque, Laura, Lung, Oliver, James, Joe, Yason, Carmencita, Banyard, Ashley C., Sullivan, Daniel, Signore, Anthony V., Lang, Andrew S., Baker, Meghan, Dawe, Beverly, Brown, Ian H., Berhane, Yohannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536465/
https://www.ncbi.nlm.nih.gov/pubmed/37766243
http://dx.doi.org/10.3390/v15091836
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author Alkie, Tamiru N.
Byrne, Alexander M. P.
Jones, Megan E. B.
Mollett, Benjamin C.
Bourque, Laura
Lung, Oliver
James, Joe
Yason, Carmencita
Banyard, Ashley C.
Sullivan, Daniel
Signore, Anthony V.
Lang, Andrew S.
Baker, Meghan
Dawe, Beverly
Brown, Ian H.
Berhane, Yohannes
author_facet Alkie, Tamiru N.
Byrne, Alexander M. P.
Jones, Megan E. B.
Mollett, Benjamin C.
Bourque, Laura
Lung, Oliver
James, Joe
Yason, Carmencita
Banyard, Ashley C.
Sullivan, Daniel
Signore, Anthony V.
Lang, Andrew S.
Baker, Meghan
Dawe, Beverly
Brown, Ian H.
Berhane, Yohannes
author_sort Alkie, Tamiru N.
collection PubMed
description In December 2022 and January 2023, we isolated clade 2.3.4.4b H5N1 high-pathogenicity avian influenza (HPAI) viruses from six American crows (Corvus brachyrhynchos) from Prince Edward Island and a red fox (Vulpes vulpes) from Newfoundland, Canada. Using full-genome sequencing and phylogenetic analysis, these viruses were found to fall into two distinct phylogenetic clusters: one group containing H5N1 viruses that had been circulating in North and South America since late 2021, and the other one containing European H5N1 viruses reported in late 2022. The transatlantic re-introduction for the second time by pelagic/Icelandic bird migration via the same route used during the 2021 incursion of Eurasian origin H5N1 viruses into North America demonstrates that migratory birds continue to be the driving force for transcontinental dissemination of the virus. This new detection further demonstrates the continual long-term threat of H5N1 viruses for poultry and mammals and the subsequent impact on various wild bird populations wherever these viruses emerge. The continual emergence of clade 2.3.4.4b H5Nx viruses requires vigilant surveillance in wild birds, particularly in areas of the Americas, which lie within the migratory corridors for long-distance migratory birds originating from Europe and Asia. Although H5Nx viruses have been detected at higher rates in North America since 2021, a bidirectional flow of H5Nx genes of American origin viruses to Europe has never been reported. In the future, coordinated and systematic surveillance programs for HPAI viruses need to be launched between European and North American agencies.
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spelling pubmed-105364652023-09-29 Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023 Alkie, Tamiru N. Byrne, Alexander M. P. Jones, Megan E. B. Mollett, Benjamin C. Bourque, Laura Lung, Oliver James, Joe Yason, Carmencita Banyard, Ashley C. Sullivan, Daniel Signore, Anthony V. Lang, Andrew S. Baker, Meghan Dawe, Beverly Brown, Ian H. Berhane, Yohannes Viruses Communication In December 2022 and January 2023, we isolated clade 2.3.4.4b H5N1 high-pathogenicity avian influenza (HPAI) viruses from six American crows (Corvus brachyrhynchos) from Prince Edward Island and a red fox (Vulpes vulpes) from Newfoundland, Canada. Using full-genome sequencing and phylogenetic analysis, these viruses were found to fall into two distinct phylogenetic clusters: one group containing H5N1 viruses that had been circulating in North and South America since late 2021, and the other one containing European H5N1 viruses reported in late 2022. The transatlantic re-introduction for the second time by pelagic/Icelandic bird migration via the same route used during the 2021 incursion of Eurasian origin H5N1 viruses into North America demonstrates that migratory birds continue to be the driving force for transcontinental dissemination of the virus. This new detection further demonstrates the continual long-term threat of H5N1 viruses for poultry and mammals and the subsequent impact on various wild bird populations wherever these viruses emerge. The continual emergence of clade 2.3.4.4b H5Nx viruses requires vigilant surveillance in wild birds, particularly in areas of the Americas, which lie within the migratory corridors for long-distance migratory birds originating from Europe and Asia. Although H5Nx viruses have been detected at higher rates in North America since 2021, a bidirectional flow of H5Nx genes of American origin viruses to Europe has never been reported. In the future, coordinated and systematic surveillance programs for HPAI viruses need to be launched between European and North American agencies. MDPI 2023-08-30 /pmc/articles/PMC10536465/ /pubmed/37766243 http://dx.doi.org/10.3390/v15091836 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Alkie, Tamiru N.
Byrne, Alexander M. P.
Jones, Megan E. B.
Mollett, Benjamin C.
Bourque, Laura
Lung, Oliver
James, Joe
Yason, Carmencita
Banyard, Ashley C.
Sullivan, Daniel
Signore, Anthony V.
Lang, Andrew S.
Baker, Meghan
Dawe, Beverly
Brown, Ian H.
Berhane, Yohannes
Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023
title Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023
title_full Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023
title_fullStr Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023
title_full_unstemmed Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023
title_short Recurring Trans-Atlantic Incursion of Clade 2.3.4.4b H5N1 Viruses by Long Distance Migratory Birds from Northern Europe to Canada in 2022/2023
title_sort recurring trans-atlantic incursion of clade 2.3.4.4b h5n1 viruses by long distance migratory birds from northern europe to canada in 2022/2023
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536465/
https://www.ncbi.nlm.nih.gov/pubmed/37766243
http://dx.doi.org/10.3390/v15091836
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