Cargando…

Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe

African swine fever (ASF) is a highly contagious and severe viral hemorrhagic disease in domestic and wild pigs. ASF seriously affects the global swine industry as the mortality rate can reach 100% with highly virulent strains. In 2007, ASF was introduced into the Caucasus and spread to Russia and l...

Descripción completa

Detalles Bibliográficos
Autores principales: Ankhanbaatar, Ulaankhuu, Auer, Agathe, Ulziibat, Gerelmaa, Settypalli, Tirumala B. K., Gombo-Ochir, Delgerzul, Basan, Ganzorig, Takemura, Taichiro, Tseren-Ochir, Erdene-Ochir, Ouled Ahmed, Hatem, Meki, Irene Kasindi, Datta, Sneha, Soumare, Baba, Metlin, Artem, Cattoli, Giovanni, Lamien, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536492/
https://www.ncbi.nlm.nih.gov/pubmed/37764951
http://dx.doi.org/10.3390/pathogens12091143
_version_ 1785112878345355264
author Ankhanbaatar, Ulaankhuu
Auer, Agathe
Ulziibat, Gerelmaa
Settypalli, Tirumala B. K.
Gombo-Ochir, Delgerzul
Basan, Ganzorig
Takemura, Taichiro
Tseren-Ochir, Erdene-Ochir
Ouled Ahmed, Hatem
Meki, Irene Kasindi
Datta, Sneha
Soumare, Baba
Metlin, Artem
Cattoli, Giovanni
Lamien, Charles E.
author_facet Ankhanbaatar, Ulaankhuu
Auer, Agathe
Ulziibat, Gerelmaa
Settypalli, Tirumala B. K.
Gombo-Ochir, Delgerzul
Basan, Ganzorig
Takemura, Taichiro
Tseren-Ochir, Erdene-Ochir
Ouled Ahmed, Hatem
Meki, Irene Kasindi
Datta, Sneha
Soumare, Baba
Metlin, Artem
Cattoli, Giovanni
Lamien, Charles E.
author_sort Ankhanbaatar, Ulaankhuu
collection PubMed
description African swine fever (ASF) is a highly contagious and severe viral hemorrhagic disease in domestic and wild pigs. ASF seriously affects the global swine industry as the mortality rate can reach 100% with highly virulent strains. In 2007, ASF was introduced into the Caucasus and spread to Russia and later into other European and Asian countries. This study reported the first whole-genome sequence (WGS) of the ASF virus (ASFV) that was detected in a Mongolian wild boar. This sequence was then compared to other WGS samples from Asia and Europe. Results show that the ASFV Genotype II from Mongolia is similar to the Asian Genotype II WGS. However, there were three nucleotide differences found between the Asian and European genome sequences, two of which were non-synonymous. It was also observed that the European Genotype II ASFV WGS was more diverse than that of the Asian counterparts. The study demonstrates that the ASFV Genotype II variants found in wild boars and domestic pigs are highly similar, suggesting these animals might have had direct or indirect contact, potentially through outdoor animal breeding. In conclusion, this study provides a WGS and mutation spectrum of the ASFV Genotype II WGS in Asia and Europe and thus provides important insights into the origin and spread of ASFV in Mongolia.
format Online
Article
Text
id pubmed-10536492
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105364922023-09-29 Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe Ankhanbaatar, Ulaankhuu Auer, Agathe Ulziibat, Gerelmaa Settypalli, Tirumala B. K. Gombo-Ochir, Delgerzul Basan, Ganzorig Takemura, Taichiro Tseren-Ochir, Erdene-Ochir Ouled Ahmed, Hatem Meki, Irene Kasindi Datta, Sneha Soumare, Baba Metlin, Artem Cattoli, Giovanni Lamien, Charles E. Pathogens Communication African swine fever (ASF) is a highly contagious and severe viral hemorrhagic disease in domestic and wild pigs. ASF seriously affects the global swine industry as the mortality rate can reach 100% with highly virulent strains. In 2007, ASF was introduced into the Caucasus and spread to Russia and later into other European and Asian countries. This study reported the first whole-genome sequence (WGS) of the ASF virus (ASFV) that was detected in a Mongolian wild boar. This sequence was then compared to other WGS samples from Asia and Europe. Results show that the ASFV Genotype II from Mongolia is similar to the Asian Genotype II WGS. However, there were three nucleotide differences found between the Asian and European genome sequences, two of which were non-synonymous. It was also observed that the European Genotype II ASFV WGS was more diverse than that of the Asian counterparts. The study demonstrates that the ASFV Genotype II variants found in wild boars and domestic pigs are highly similar, suggesting these animals might have had direct or indirect contact, potentially through outdoor animal breeding. In conclusion, this study provides a WGS and mutation spectrum of the ASFV Genotype II WGS in Asia and Europe and thus provides important insights into the origin and spread of ASFV in Mongolia. MDPI 2023-09-07 /pmc/articles/PMC10536492/ /pubmed/37764951 http://dx.doi.org/10.3390/pathogens12091143 Text en © FAO, 2023. https://creativecommons.org/licenses/by-nc-sa/3.0/igo/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY NC SA) license (https://creativecommons.org/licenses/by-nc-sa/3.0/igo/).
spellingShingle Communication
Ankhanbaatar, Ulaankhuu
Auer, Agathe
Ulziibat, Gerelmaa
Settypalli, Tirumala B. K.
Gombo-Ochir, Delgerzul
Basan, Ganzorig
Takemura, Taichiro
Tseren-Ochir, Erdene-Ochir
Ouled Ahmed, Hatem
Meki, Irene Kasindi
Datta, Sneha
Soumare, Baba
Metlin, Artem
Cattoli, Giovanni
Lamien, Charles E.
Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe
title Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe
title_full Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe
title_fullStr Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe
title_full_unstemmed Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe
title_short Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe
title_sort comparison of the whole-genome sequence of the african swine fever virus from a mongolian wild boar with genotype ii viruses from asia and europe
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536492/
https://www.ncbi.nlm.nih.gov/pubmed/37764951
http://dx.doi.org/10.3390/pathogens12091143
work_keys_str_mv AT ankhanbaatarulaankhuu comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT aueragathe comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT ulziibatgerelmaa comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT settypallitirumalabk comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT gomboochirdelgerzul comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT basanganzorig comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT takemurataichiro comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT tserenochirerdeneochir comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT ouledahmedhatem comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT mekiirenekasindi comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT dattasneha comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT soumarebaba comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT metlinartem comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT cattoligiovanni comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope
AT lamiencharlese comparisonofthewholegenomesequenceoftheafricanswinefevervirusfromamongolianwildboarwithgenotypeiivirusesfromasiaandeurope