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Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe
African swine fever (ASF) is a highly contagious and severe viral hemorrhagic disease in domestic and wild pigs. ASF seriously affects the global swine industry as the mortality rate can reach 100% with highly virulent strains. In 2007, ASF was introduced into the Caucasus and spread to Russia and l...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536492/ https://www.ncbi.nlm.nih.gov/pubmed/37764951 http://dx.doi.org/10.3390/pathogens12091143 |
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author | Ankhanbaatar, Ulaankhuu Auer, Agathe Ulziibat, Gerelmaa Settypalli, Tirumala B. K. Gombo-Ochir, Delgerzul Basan, Ganzorig Takemura, Taichiro Tseren-Ochir, Erdene-Ochir Ouled Ahmed, Hatem Meki, Irene Kasindi Datta, Sneha Soumare, Baba Metlin, Artem Cattoli, Giovanni Lamien, Charles E. |
author_facet | Ankhanbaatar, Ulaankhuu Auer, Agathe Ulziibat, Gerelmaa Settypalli, Tirumala B. K. Gombo-Ochir, Delgerzul Basan, Ganzorig Takemura, Taichiro Tseren-Ochir, Erdene-Ochir Ouled Ahmed, Hatem Meki, Irene Kasindi Datta, Sneha Soumare, Baba Metlin, Artem Cattoli, Giovanni Lamien, Charles E. |
author_sort | Ankhanbaatar, Ulaankhuu |
collection | PubMed |
description | African swine fever (ASF) is a highly contagious and severe viral hemorrhagic disease in domestic and wild pigs. ASF seriously affects the global swine industry as the mortality rate can reach 100% with highly virulent strains. In 2007, ASF was introduced into the Caucasus and spread to Russia and later into other European and Asian countries. This study reported the first whole-genome sequence (WGS) of the ASF virus (ASFV) that was detected in a Mongolian wild boar. This sequence was then compared to other WGS samples from Asia and Europe. Results show that the ASFV Genotype II from Mongolia is similar to the Asian Genotype II WGS. However, there were three nucleotide differences found between the Asian and European genome sequences, two of which were non-synonymous. It was also observed that the European Genotype II ASFV WGS was more diverse than that of the Asian counterparts. The study demonstrates that the ASFV Genotype II variants found in wild boars and domestic pigs are highly similar, suggesting these animals might have had direct or indirect contact, potentially through outdoor animal breeding. In conclusion, this study provides a WGS and mutation spectrum of the ASFV Genotype II WGS in Asia and Europe and thus provides important insights into the origin and spread of ASFV in Mongolia. |
format | Online Article Text |
id | pubmed-10536492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105364922023-09-29 Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe Ankhanbaatar, Ulaankhuu Auer, Agathe Ulziibat, Gerelmaa Settypalli, Tirumala B. K. Gombo-Ochir, Delgerzul Basan, Ganzorig Takemura, Taichiro Tseren-Ochir, Erdene-Ochir Ouled Ahmed, Hatem Meki, Irene Kasindi Datta, Sneha Soumare, Baba Metlin, Artem Cattoli, Giovanni Lamien, Charles E. Pathogens Communication African swine fever (ASF) is a highly contagious and severe viral hemorrhagic disease in domestic and wild pigs. ASF seriously affects the global swine industry as the mortality rate can reach 100% with highly virulent strains. In 2007, ASF was introduced into the Caucasus and spread to Russia and later into other European and Asian countries. This study reported the first whole-genome sequence (WGS) of the ASF virus (ASFV) that was detected in a Mongolian wild boar. This sequence was then compared to other WGS samples from Asia and Europe. Results show that the ASFV Genotype II from Mongolia is similar to the Asian Genotype II WGS. However, there were three nucleotide differences found between the Asian and European genome sequences, two of which were non-synonymous. It was also observed that the European Genotype II ASFV WGS was more diverse than that of the Asian counterparts. The study demonstrates that the ASFV Genotype II variants found in wild boars and domestic pigs are highly similar, suggesting these animals might have had direct or indirect contact, potentially through outdoor animal breeding. In conclusion, this study provides a WGS and mutation spectrum of the ASFV Genotype II WGS in Asia and Europe and thus provides important insights into the origin and spread of ASFV in Mongolia. MDPI 2023-09-07 /pmc/articles/PMC10536492/ /pubmed/37764951 http://dx.doi.org/10.3390/pathogens12091143 Text en © FAO, 2023. https://creativecommons.org/licenses/by-nc-sa/3.0/igo/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY NC SA) license (https://creativecommons.org/licenses/by-nc-sa/3.0/igo/). |
spellingShingle | Communication Ankhanbaatar, Ulaankhuu Auer, Agathe Ulziibat, Gerelmaa Settypalli, Tirumala B. K. Gombo-Ochir, Delgerzul Basan, Ganzorig Takemura, Taichiro Tseren-Ochir, Erdene-Ochir Ouled Ahmed, Hatem Meki, Irene Kasindi Datta, Sneha Soumare, Baba Metlin, Artem Cattoli, Giovanni Lamien, Charles E. Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe |
title | Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe |
title_full | Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe |
title_fullStr | Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe |
title_full_unstemmed | Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe |
title_short | Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe |
title_sort | comparison of the whole-genome sequence of the african swine fever virus from a mongolian wild boar with genotype ii viruses from asia and europe |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536492/ https://www.ncbi.nlm.nih.gov/pubmed/37764951 http://dx.doi.org/10.3390/pathogens12091143 |
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