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Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

The progression of Alzheimer’s disease (AD) correlates with the propagation of hyperphosphorylated tau (pTau) from the entorhinal cortex to the hippocampus and neocortex. Neutral sphingomyelinase2 (nSMase2) is critical in the biosynthesis of extracellular vesicles (EVs), which play a role in pTau pr...

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Detalles Bibliográficos
Autores principales:	Huang, Meixiang, Tallon, Carolyn, Zhu, Xiaolei, Huizar, Kaitlyn D. J., Picciolini, Silvia, Thomas, Ajit G., Tenora, Lukas, Liyanage, Wathsala, Rodà, Francesca, Gualerzi, Alice, Kannan, Rangaramanujam M., Bedoni, Marzia, Rais, Rana, Slusher, Barbara S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536502/ https://www.ncbi.nlm.nih.gov/pubmed/37765332 http://dx.doi.org/10.3390/pharmaceutics15092364

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