An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines

Recently, a great effort has been devoted to studying attenuated and subunit vaccine development against SARS-CoV-2 since its outbreak in December 2019. It is known that diverse virus-like particles (VLPs) are extensively employed as carriers to display various antigenic and immunostimulatory cargo...

Descripción completa

Detalles Bibliográficos
Autores principales: Setyo Utomo, Doddy Irawan, Suhaimi, Hamizah, Muhammad Azami, Nor Azila, Azmi, Fazren, Mohd Amin, Mohd Cairul Iqbal, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536610/
https://www.ncbi.nlm.nih.gov/pubmed/37766182
http://dx.doi.org/10.3390/vaccines11091506
_version_ 1785112907951898624
author Setyo Utomo, Doddy Irawan
Suhaimi, Hamizah
Muhammad Azami, Nor Azila
Azmi, Fazren
Mohd Amin, Mohd Cairul Iqbal
Xu, Jian
author_facet Setyo Utomo, Doddy Irawan
Suhaimi, Hamizah
Muhammad Azami, Nor Azila
Azmi, Fazren
Mohd Amin, Mohd Cairul Iqbal
Xu, Jian
author_sort Setyo Utomo, Doddy Irawan
collection PubMed
description Recently, a great effort has been devoted to studying attenuated and subunit vaccine development against SARS-CoV-2 since its outbreak in December 2019. It is known that diverse virus-like particles (VLPs) are extensively employed as carriers to display various antigenic and immunostimulatory cargo modules for vaccine development. Single or multiple antigens or antigenic domains such as the spike or nucleocapsid protein or their variants from SARS-CoV-2 could also be incorporated into VLPs via either a genetic or chemical display approach. Such antigen display platforms would help screen safer and more effective vaccine candidates capable of generating a strong immune response with or without adjuvant. This review aims to provide valuable insights for the future development of SARS-CoV-2 VLP vaccines by summarizing the latest updates and perspectives on the vaccine development of VLP platforms for genetic and chemical displaying antigens from SARS-CoV-2.
format Online
Article
Text
id pubmed-10536610
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105366102023-09-29 An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines Setyo Utomo, Doddy Irawan Suhaimi, Hamizah Muhammad Azami, Nor Azila Azmi, Fazren Mohd Amin, Mohd Cairul Iqbal Xu, Jian Vaccines (Basel) Review Recently, a great effort has been devoted to studying attenuated and subunit vaccine development against SARS-CoV-2 since its outbreak in December 2019. It is known that diverse virus-like particles (VLPs) are extensively employed as carriers to display various antigenic and immunostimulatory cargo modules for vaccine development. Single or multiple antigens or antigenic domains such as the spike or nucleocapsid protein or their variants from SARS-CoV-2 could also be incorporated into VLPs via either a genetic or chemical display approach. Such antigen display platforms would help screen safer and more effective vaccine candidates capable of generating a strong immune response with or without adjuvant. This review aims to provide valuable insights for the future development of SARS-CoV-2 VLP vaccines by summarizing the latest updates and perspectives on the vaccine development of VLP platforms for genetic and chemical displaying antigens from SARS-CoV-2. MDPI 2023-09-20 /pmc/articles/PMC10536610/ /pubmed/37766182 http://dx.doi.org/10.3390/vaccines11091506 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Setyo Utomo, Doddy Irawan
Suhaimi, Hamizah
Muhammad Azami, Nor Azila
Azmi, Fazren
Mohd Amin, Mohd Cairul Iqbal
Xu, Jian
An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines
title An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines
title_full An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines
title_fullStr An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines
title_full_unstemmed An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines
title_short An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines
title_sort overview of recent developments in the application of antigen displaying vaccine platforms: hints for future sars-cov-2 vlp vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536610/
https://www.ncbi.nlm.nih.gov/pubmed/37766182
http://dx.doi.org/10.3390/vaccines11091506
work_keys_str_mv AT setyoutomododdyirawan anoverviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT suhaimihamizah anoverviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT muhammadazaminorazila anoverviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT azmifazren anoverviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT mohdaminmohdcairuliqbal anoverviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT xujian anoverviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT setyoutomododdyirawan overviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT suhaimihamizah overviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT muhammadazaminorazila overviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT azmifazren overviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT mohdaminmohdcairuliqbal overviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines
AT xujian overviewofrecentdevelopmentsintheapplicationofantigendisplayingvaccineplatformshintsforfuturesarscov2vlpvaccines

Ejemplares similares