Cargando…
Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome
Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quanti...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536633/ https://www.ncbi.nlm.nih.gov/pubmed/37764766 http://dx.doi.org/10.3390/nu15183982 |
_version_ | 1785112913400299520 |
---|---|
author | Fourati, Salma Hamon, Annick Daclat, Rita Salem, Joe-Elie Peoc’h, Katell Le Beyec, Johanne Joly, Francisca Lacorte, Jean-Marc |
author_facet | Fourati, Salma Hamon, Annick Daclat, Rita Salem, Joe-Elie Peoc’h, Katell Le Beyec, Johanne Joly, Francisca Lacorte, Jean-Marc |
author_sort | Fourati, Salma |
collection | PubMed |
description | Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quantified apolipoprotein B-48 (ApoB-48), which is exclusively synthesized by enterocytes and secreted associated with dietary lipids and investigated the relationship between ApoB-48 and clinical and biological data as well as PN dependence. A total of 51 adult patients were included, 36 of whom were PN-dependent. We found a robust positive correlation between circulating ApoB-48 and residual small bowel length, which was also found in the subgroup of patients with jejunocolic anastomosis. Fasting ApoB-48 levels were significantly lower in PN-dependent patients than in PN-weaned patients and negatively correlated with parenteral nutrition dependence. Our results suggest that ApoB-48 could be proposed as a marker of intestinal absorptive function and could be an interesting follow-up marker in patients with SBS. |
format | Online Article Text |
id | pubmed-10536633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105366332023-09-29 Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome Fourati, Salma Hamon, Annick Daclat, Rita Salem, Joe-Elie Peoc’h, Katell Le Beyec, Johanne Joly, Francisca Lacorte, Jean-Marc Nutrients Article Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quantified apolipoprotein B-48 (ApoB-48), which is exclusively synthesized by enterocytes and secreted associated with dietary lipids and investigated the relationship between ApoB-48 and clinical and biological data as well as PN dependence. A total of 51 adult patients were included, 36 of whom were PN-dependent. We found a robust positive correlation between circulating ApoB-48 and residual small bowel length, which was also found in the subgroup of patients with jejunocolic anastomosis. Fasting ApoB-48 levels were significantly lower in PN-dependent patients than in PN-weaned patients and negatively correlated with parenteral nutrition dependence. Our results suggest that ApoB-48 could be proposed as a marker of intestinal absorptive function and could be an interesting follow-up marker in patients with SBS. MDPI 2023-09-14 /pmc/articles/PMC10536633/ /pubmed/37764766 http://dx.doi.org/10.3390/nu15183982 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fourati, Salma Hamon, Annick Daclat, Rita Salem, Joe-Elie Peoc’h, Katell Le Beyec, Johanne Joly, Francisca Lacorte, Jean-Marc Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome |
title | Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome |
title_full | Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome |
title_fullStr | Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome |
title_full_unstemmed | Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome |
title_short | Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome |
title_sort | circulating apolipoprotein b-48 as a biomarker of parenteral nutrition dependence in adult patients with short bowel syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536633/ https://www.ncbi.nlm.nih.gov/pubmed/37764766 http://dx.doi.org/10.3390/nu15183982 |
work_keys_str_mv | AT fouratisalma circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome AT hamonannick circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome AT daclatrita circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome AT salemjoeelie circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome AT peochkatell circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome AT lebeyecjohanne circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome AT jolyfrancisca circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome AT lacortejeanmarc circulatingapolipoproteinb48asabiomarkerofparenteralnutritiondependenceinadultpatientswithshortbowelsyndrome |