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Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome

Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quanti...

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Autores principales: Fourati, Salma, Hamon, Annick, Daclat, Rita, Salem, Joe-Elie, Peoc’h, Katell, Le Beyec, Johanne, Joly, Francisca, Lacorte, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536633/
https://www.ncbi.nlm.nih.gov/pubmed/37764766
http://dx.doi.org/10.3390/nu15183982
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author Fourati, Salma
Hamon, Annick
Daclat, Rita
Salem, Joe-Elie
Peoc’h, Katell
Le Beyec, Johanne
Joly, Francisca
Lacorte, Jean-Marc
author_facet Fourati, Salma
Hamon, Annick
Daclat, Rita
Salem, Joe-Elie
Peoc’h, Katell
Le Beyec, Johanne
Joly, Francisca
Lacorte, Jean-Marc
author_sort Fourati, Salma
collection PubMed
description Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quantified apolipoprotein B-48 (ApoB-48), which is exclusively synthesized by enterocytes and secreted associated with dietary lipids and investigated the relationship between ApoB-48 and clinical and biological data as well as PN dependence. A total of 51 adult patients were included, 36 of whom were PN-dependent. We found a robust positive correlation between circulating ApoB-48 and residual small bowel length, which was also found in the subgroup of patients with jejunocolic anastomosis. Fasting ApoB-48 levels were significantly lower in PN-dependent patients than in PN-weaned patients and negatively correlated with parenteral nutrition dependence. Our results suggest that ApoB-48 could be proposed as a marker of intestinal absorptive function and could be an interesting follow-up marker in patients with SBS.
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spelling pubmed-105366332023-09-29 Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome Fourati, Salma Hamon, Annick Daclat, Rita Salem, Joe-Elie Peoc’h, Katell Le Beyec, Johanne Joly, Francisca Lacorte, Jean-Marc Nutrients Article Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quantified apolipoprotein B-48 (ApoB-48), which is exclusively synthesized by enterocytes and secreted associated with dietary lipids and investigated the relationship between ApoB-48 and clinical and biological data as well as PN dependence. A total of 51 adult patients were included, 36 of whom were PN-dependent. We found a robust positive correlation between circulating ApoB-48 and residual small bowel length, which was also found in the subgroup of patients with jejunocolic anastomosis. Fasting ApoB-48 levels were significantly lower in PN-dependent patients than in PN-weaned patients and negatively correlated with parenteral nutrition dependence. Our results suggest that ApoB-48 could be proposed as a marker of intestinal absorptive function and could be an interesting follow-up marker in patients with SBS. MDPI 2023-09-14 /pmc/articles/PMC10536633/ /pubmed/37764766 http://dx.doi.org/10.3390/nu15183982 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fourati, Salma
Hamon, Annick
Daclat, Rita
Salem, Joe-Elie
Peoc’h, Katell
Le Beyec, Johanne
Joly, Francisca
Lacorte, Jean-Marc
Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome
title Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome
title_full Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome
title_fullStr Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome
title_full_unstemmed Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome
title_short Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome
title_sort circulating apolipoprotein b-48 as a biomarker of parenteral nutrition dependence in adult patients with short bowel syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536633/
https://www.ncbi.nlm.nih.gov/pubmed/37764766
http://dx.doi.org/10.3390/nu15183982
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