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Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies

Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential f...

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Autores principales: Castilho de Arruda, Larissa Domingues, Giovanetti, Marta, Fonseca, Vagner, Zardin, Marina Castilhos Souza Umaki, Lichs, Gislene Garcia de Castro, Asato, Silvia, Esposito, Ana Olivia Pascoto, Tokeshi Müller, Miriam, Xavier, Joilson, Fritsch, Hegger, Lima, Mauricio, de Oliveira, Carla, Santos, Elaine Vieira, Maziero, Livia de Mello Almeida, Frias, Danila Fernanda Rodrigues, Ahad das Neves, Danielle, Ferreira da Silva, Liliane, Rodrigues Barretos, Ellen Caroline, Tsuha Oshiro, Paulo Eduardo, Modafari Goday, Bianca, Lemos dos Santos, Jéssica Klener, Kashima, Simone, de Albuquerque, Carlos F. C., Said, Rodrigo Fabiano do Carmo, Rosewell, Alexander, Demarchi, Luiz Henrique Ferraz, Croda, Julio, Alcantara, Luiz Carlos Junior, Cavalheiro Maymone Gonçalves, Crhistinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536684/
https://www.ncbi.nlm.nih.gov/pubmed/37766197
http://dx.doi.org/10.3390/v15091790
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author Castilho de Arruda, Larissa Domingues
Giovanetti, Marta
Fonseca, Vagner
Zardin, Marina Castilhos Souza Umaki
Lichs, Gislene Garcia de Castro
Asato, Silvia
Esposito, Ana Olivia Pascoto
Tokeshi Müller, Miriam
Xavier, Joilson
Fritsch, Hegger
Lima, Mauricio
de Oliveira, Carla
Santos, Elaine Vieira
Maziero, Livia de Mello Almeida
Frias, Danila Fernanda Rodrigues
Ahad das Neves, Danielle
Ferreira da Silva, Liliane
Rodrigues Barretos, Ellen Caroline
Tsuha Oshiro, Paulo Eduardo
Modafari Goday, Bianca
Lemos dos Santos, Jéssica Klener
Kashima, Simone
de Albuquerque, Carlos F. C.
Said, Rodrigo Fabiano do Carmo
Rosewell, Alexander
Demarchi, Luiz Henrique Ferraz
Croda, Julio
Alcantara, Luiz Carlos Junior
Cavalheiro Maymone Gonçalves, Crhistinne
author_facet Castilho de Arruda, Larissa Domingues
Giovanetti, Marta
Fonseca, Vagner
Zardin, Marina Castilhos Souza Umaki
Lichs, Gislene Garcia de Castro
Asato, Silvia
Esposito, Ana Olivia Pascoto
Tokeshi Müller, Miriam
Xavier, Joilson
Fritsch, Hegger
Lima, Mauricio
de Oliveira, Carla
Santos, Elaine Vieira
Maziero, Livia de Mello Almeida
Frias, Danila Fernanda Rodrigues
Ahad das Neves, Danielle
Ferreira da Silva, Liliane
Rodrigues Barretos, Ellen Caroline
Tsuha Oshiro, Paulo Eduardo
Modafari Goday, Bianca
Lemos dos Santos, Jéssica Klener
Kashima, Simone
de Albuquerque, Carlos F. C.
Said, Rodrigo Fabiano do Carmo
Rosewell, Alexander
Demarchi, Luiz Henrique Ferraz
Croda, Julio
Alcantara, Luiz Carlos Junior
Cavalheiro Maymone Gonçalves, Crhistinne
author_sort Castilho de Arruda, Larissa Domingues
collection PubMed
description Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential for implementing effective disease control and prevention measures. In response to this urgent need, we conducted an on-site training program in genomic surveillance in collaboration with the Central Laboratory of Health and the Secretary of Health of the Mato Grosso do Sul state. This initiative resulted in the generation of 177 DENV genome sequences collected between May 2021 and May 2022, a period during which over 11,391 dengue fever cases were reported in the state. Through this approach, we were able to identify the co-circulation of two different dengue serotypes (DENV1 and DENV2) as well as the existence of diverse viral lineages within each genotype, suggesting that multiple introduction events of different viral strains occurred in the region. By integrating epidemiological data, our findings unveiled temporal fluctuations in the relative abundance of different serotypes throughout various epidemic seasons, highlighting the complex and changing dynamics of DENV transmission throughout time. These findings demonstrate the value of ongoing surveillance activities in tracking viral transmission patterns, monitoring viral evolution, and informing public health actions.
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spelling pubmed-105366842023-09-29 Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies Castilho de Arruda, Larissa Domingues Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki Lichs, Gislene Garcia de Castro Asato, Silvia Esposito, Ana Olivia Pascoto Tokeshi Müller, Miriam Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Maziero, Livia de Mello Almeida Frias, Danila Fernanda Rodrigues Ahad das Neves, Danielle Ferreira da Silva, Liliane Rodrigues Barretos, Ellen Caroline Tsuha Oshiro, Paulo Eduardo Modafari Goday, Bianca Lemos dos Santos, Jéssica Klener Kashima, Simone de Albuquerque, Carlos F. C. Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Demarchi, Luiz Henrique Ferraz Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne Viruses Article Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential for implementing effective disease control and prevention measures. In response to this urgent need, we conducted an on-site training program in genomic surveillance in collaboration with the Central Laboratory of Health and the Secretary of Health of the Mato Grosso do Sul state. This initiative resulted in the generation of 177 DENV genome sequences collected between May 2021 and May 2022, a period during which over 11,391 dengue fever cases were reported in the state. Through this approach, we were able to identify the co-circulation of two different dengue serotypes (DENV1 and DENV2) as well as the existence of diverse viral lineages within each genotype, suggesting that multiple introduction events of different viral strains occurred in the region. By integrating epidemiological data, our findings unveiled temporal fluctuations in the relative abundance of different serotypes throughout various epidemic seasons, highlighting the complex and changing dynamics of DENV transmission throughout time. These findings demonstrate the value of ongoing surveillance activities in tracking viral transmission patterns, monitoring viral evolution, and informing public health actions. MDPI 2023-08-23 /pmc/articles/PMC10536684/ /pubmed/37766197 http://dx.doi.org/10.3390/v15091790 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castilho de Arruda, Larissa Domingues
Giovanetti, Marta
Fonseca, Vagner
Zardin, Marina Castilhos Souza Umaki
Lichs, Gislene Garcia de Castro
Asato, Silvia
Esposito, Ana Olivia Pascoto
Tokeshi Müller, Miriam
Xavier, Joilson
Fritsch, Hegger
Lima, Mauricio
de Oliveira, Carla
Santos, Elaine Vieira
Maziero, Livia de Mello Almeida
Frias, Danila Fernanda Rodrigues
Ahad das Neves, Danielle
Ferreira da Silva, Liliane
Rodrigues Barretos, Ellen Caroline
Tsuha Oshiro, Paulo Eduardo
Modafari Goday, Bianca
Lemos dos Santos, Jéssica Klener
Kashima, Simone
de Albuquerque, Carlos F. C.
Said, Rodrigo Fabiano do Carmo
Rosewell, Alexander
Demarchi, Luiz Henrique Ferraz
Croda, Julio
Alcantara, Luiz Carlos Junior
Cavalheiro Maymone Gonçalves, Crhistinne
Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
title Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
title_full Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
title_fullStr Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
title_full_unstemmed Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
title_short Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
title_sort dengue fever surveillance in mato grosso do sul: insights from genomic analysis and implications for public health strategies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536684/
https://www.ncbi.nlm.nih.gov/pubmed/37766197
http://dx.doi.org/10.3390/v15091790
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