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Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential f...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536684/ https://www.ncbi.nlm.nih.gov/pubmed/37766197 http://dx.doi.org/10.3390/v15091790 |
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author | Castilho de Arruda, Larissa Domingues Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki Lichs, Gislene Garcia de Castro Asato, Silvia Esposito, Ana Olivia Pascoto Tokeshi Müller, Miriam Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Maziero, Livia de Mello Almeida Frias, Danila Fernanda Rodrigues Ahad das Neves, Danielle Ferreira da Silva, Liliane Rodrigues Barretos, Ellen Caroline Tsuha Oshiro, Paulo Eduardo Modafari Goday, Bianca Lemos dos Santos, Jéssica Klener Kashima, Simone de Albuquerque, Carlos F. C. Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Demarchi, Luiz Henrique Ferraz Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne |
author_facet | Castilho de Arruda, Larissa Domingues Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki Lichs, Gislene Garcia de Castro Asato, Silvia Esposito, Ana Olivia Pascoto Tokeshi Müller, Miriam Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Maziero, Livia de Mello Almeida Frias, Danila Fernanda Rodrigues Ahad das Neves, Danielle Ferreira da Silva, Liliane Rodrigues Barretos, Ellen Caroline Tsuha Oshiro, Paulo Eduardo Modafari Goday, Bianca Lemos dos Santos, Jéssica Klener Kashima, Simone de Albuquerque, Carlos F. C. Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Demarchi, Luiz Henrique Ferraz Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne |
author_sort | Castilho de Arruda, Larissa Domingues |
collection | PubMed |
description | Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential for implementing effective disease control and prevention measures. In response to this urgent need, we conducted an on-site training program in genomic surveillance in collaboration with the Central Laboratory of Health and the Secretary of Health of the Mato Grosso do Sul state. This initiative resulted in the generation of 177 DENV genome sequences collected between May 2021 and May 2022, a period during which over 11,391 dengue fever cases were reported in the state. Through this approach, we were able to identify the co-circulation of two different dengue serotypes (DENV1 and DENV2) as well as the existence of diverse viral lineages within each genotype, suggesting that multiple introduction events of different viral strains occurred in the region. By integrating epidemiological data, our findings unveiled temporal fluctuations in the relative abundance of different serotypes throughout various epidemic seasons, highlighting the complex and changing dynamics of DENV transmission throughout time. These findings demonstrate the value of ongoing surveillance activities in tracking viral transmission patterns, monitoring viral evolution, and informing public health actions. |
format | Online Article Text |
id | pubmed-10536684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105366842023-09-29 Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies Castilho de Arruda, Larissa Domingues Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki Lichs, Gislene Garcia de Castro Asato, Silvia Esposito, Ana Olivia Pascoto Tokeshi Müller, Miriam Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Maziero, Livia de Mello Almeida Frias, Danila Fernanda Rodrigues Ahad das Neves, Danielle Ferreira da Silva, Liliane Rodrigues Barretos, Ellen Caroline Tsuha Oshiro, Paulo Eduardo Modafari Goday, Bianca Lemos dos Santos, Jéssica Klener Kashima, Simone de Albuquerque, Carlos F. C. Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Demarchi, Luiz Henrique Ferraz Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne Viruses Article Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential for implementing effective disease control and prevention measures. In response to this urgent need, we conducted an on-site training program in genomic surveillance in collaboration with the Central Laboratory of Health and the Secretary of Health of the Mato Grosso do Sul state. This initiative resulted in the generation of 177 DENV genome sequences collected between May 2021 and May 2022, a period during which over 11,391 dengue fever cases were reported in the state. Through this approach, we were able to identify the co-circulation of two different dengue serotypes (DENV1 and DENV2) as well as the existence of diverse viral lineages within each genotype, suggesting that multiple introduction events of different viral strains occurred in the region. By integrating epidemiological data, our findings unveiled temporal fluctuations in the relative abundance of different serotypes throughout various epidemic seasons, highlighting the complex and changing dynamics of DENV transmission throughout time. These findings demonstrate the value of ongoing surveillance activities in tracking viral transmission patterns, monitoring viral evolution, and informing public health actions. MDPI 2023-08-23 /pmc/articles/PMC10536684/ /pubmed/37766197 http://dx.doi.org/10.3390/v15091790 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Castilho de Arruda, Larissa Domingues Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki Lichs, Gislene Garcia de Castro Asato, Silvia Esposito, Ana Olivia Pascoto Tokeshi Müller, Miriam Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Maziero, Livia de Mello Almeida Frias, Danila Fernanda Rodrigues Ahad das Neves, Danielle Ferreira da Silva, Liliane Rodrigues Barretos, Ellen Caroline Tsuha Oshiro, Paulo Eduardo Modafari Goday, Bianca Lemos dos Santos, Jéssica Klener Kashima, Simone de Albuquerque, Carlos F. C. Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Demarchi, Luiz Henrique Ferraz Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies |
title | Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies |
title_full | Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies |
title_fullStr | Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies |
title_full_unstemmed | Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies |
title_short | Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies |
title_sort | dengue fever surveillance in mato grosso do sul: insights from genomic analysis and implications for public health strategies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536684/ https://www.ncbi.nlm.nih.gov/pubmed/37766197 http://dx.doi.org/10.3390/v15091790 |
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