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Bacterial Outer Membrane Vesicles and Immune Modulation of the Host

This article reviews the role of outer membrane vesicles (OMVs) in mediating the interaction between Gram-negative bacteria and their human hosts. OMVs are produced by a diverse range of Gram-negative bacteria during infection and play a critical role in facilitating host–pathogen interactions witho...

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Detalles Bibliográficos
Autores principales: Charpentier, Lily A., Dolben, Emily F., Hendricks, Matthew R., Hogan, Deborah A., Bomberger, Jennifer M., Stanton, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536716/
https://www.ncbi.nlm.nih.gov/pubmed/37755174
http://dx.doi.org/10.3390/membranes13090752
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author Charpentier, Lily A.
Dolben, Emily F.
Hendricks, Matthew R.
Hogan, Deborah A.
Bomberger, Jennifer M.
Stanton, Bruce A.
author_facet Charpentier, Lily A.
Dolben, Emily F.
Hendricks, Matthew R.
Hogan, Deborah A.
Bomberger, Jennifer M.
Stanton, Bruce A.
author_sort Charpentier, Lily A.
collection PubMed
description This article reviews the role of outer membrane vesicles (OMVs) in mediating the interaction between Gram-negative bacteria and their human hosts. OMVs are produced by a diverse range of Gram-negative bacteria during infection and play a critical role in facilitating host–pathogen interactions without requiring direct cell-to-cell contact. This article describes the mechanisms by which OMVs are formed and subsequently interact with host cells, leading to the transport of microbial protein virulence factors and short interfering RNAs (sRNA) to their host targets, exerting their immunomodulatory effects by targeting specific host signaling pathways. Specifically, this review highlights mechanisms by which OMVs facilitate chronic infection through epigenetic modification of the host immune response. Finally, this review identifies critical knowledge gaps in the field and offers potential avenues for future OMV research, specifically regarding rigor and reproducibility in OMV isolation and characterization methods.
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spelling pubmed-105367162023-09-29 Bacterial Outer Membrane Vesicles and Immune Modulation of the Host Charpentier, Lily A. Dolben, Emily F. Hendricks, Matthew R. Hogan, Deborah A. Bomberger, Jennifer M. Stanton, Bruce A. Membranes (Basel) Review This article reviews the role of outer membrane vesicles (OMVs) in mediating the interaction between Gram-negative bacteria and their human hosts. OMVs are produced by a diverse range of Gram-negative bacteria during infection and play a critical role in facilitating host–pathogen interactions without requiring direct cell-to-cell contact. This article describes the mechanisms by which OMVs are formed and subsequently interact with host cells, leading to the transport of microbial protein virulence factors and short interfering RNAs (sRNA) to their host targets, exerting their immunomodulatory effects by targeting specific host signaling pathways. Specifically, this review highlights mechanisms by which OMVs facilitate chronic infection through epigenetic modification of the host immune response. Finally, this review identifies critical knowledge gaps in the field and offers potential avenues for future OMV research, specifically regarding rigor and reproducibility in OMV isolation and characterization methods. MDPI 2023-08-24 /pmc/articles/PMC10536716/ /pubmed/37755174 http://dx.doi.org/10.3390/membranes13090752 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Charpentier, Lily A.
Dolben, Emily F.
Hendricks, Matthew R.
Hogan, Deborah A.
Bomberger, Jennifer M.
Stanton, Bruce A.
Bacterial Outer Membrane Vesicles and Immune Modulation of the Host
title Bacterial Outer Membrane Vesicles and Immune Modulation of the Host
title_full Bacterial Outer Membrane Vesicles and Immune Modulation of the Host
title_fullStr Bacterial Outer Membrane Vesicles and Immune Modulation of the Host
title_full_unstemmed Bacterial Outer Membrane Vesicles and Immune Modulation of the Host
title_short Bacterial Outer Membrane Vesicles and Immune Modulation of the Host
title_sort bacterial outer membrane vesicles and immune modulation of the host
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536716/
https://www.ncbi.nlm.nih.gov/pubmed/37755174
http://dx.doi.org/10.3390/membranes13090752
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