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Bacterial Outer Membrane Vesicles and Immune Modulation of the Host
This article reviews the role of outer membrane vesicles (OMVs) in mediating the interaction between Gram-negative bacteria and their human hosts. OMVs are produced by a diverse range of Gram-negative bacteria during infection and play a critical role in facilitating host–pathogen interactions witho...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536716/ https://www.ncbi.nlm.nih.gov/pubmed/37755174 http://dx.doi.org/10.3390/membranes13090752 |
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author | Charpentier, Lily A. Dolben, Emily F. Hendricks, Matthew R. Hogan, Deborah A. Bomberger, Jennifer M. Stanton, Bruce A. |
author_facet | Charpentier, Lily A. Dolben, Emily F. Hendricks, Matthew R. Hogan, Deborah A. Bomberger, Jennifer M. Stanton, Bruce A. |
author_sort | Charpentier, Lily A. |
collection | PubMed |
description | This article reviews the role of outer membrane vesicles (OMVs) in mediating the interaction between Gram-negative bacteria and their human hosts. OMVs are produced by a diverse range of Gram-negative bacteria during infection and play a critical role in facilitating host–pathogen interactions without requiring direct cell-to-cell contact. This article describes the mechanisms by which OMVs are formed and subsequently interact with host cells, leading to the transport of microbial protein virulence factors and short interfering RNAs (sRNA) to their host targets, exerting their immunomodulatory effects by targeting specific host signaling pathways. Specifically, this review highlights mechanisms by which OMVs facilitate chronic infection through epigenetic modification of the host immune response. Finally, this review identifies critical knowledge gaps in the field and offers potential avenues for future OMV research, specifically regarding rigor and reproducibility in OMV isolation and characterization methods. |
format | Online Article Text |
id | pubmed-10536716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105367162023-09-29 Bacterial Outer Membrane Vesicles and Immune Modulation of the Host Charpentier, Lily A. Dolben, Emily F. Hendricks, Matthew R. Hogan, Deborah A. Bomberger, Jennifer M. Stanton, Bruce A. Membranes (Basel) Review This article reviews the role of outer membrane vesicles (OMVs) in mediating the interaction between Gram-negative bacteria and their human hosts. OMVs are produced by a diverse range of Gram-negative bacteria during infection and play a critical role in facilitating host–pathogen interactions without requiring direct cell-to-cell contact. This article describes the mechanisms by which OMVs are formed and subsequently interact with host cells, leading to the transport of microbial protein virulence factors and short interfering RNAs (sRNA) to their host targets, exerting their immunomodulatory effects by targeting specific host signaling pathways. Specifically, this review highlights mechanisms by which OMVs facilitate chronic infection through epigenetic modification of the host immune response. Finally, this review identifies critical knowledge gaps in the field and offers potential avenues for future OMV research, specifically regarding rigor and reproducibility in OMV isolation and characterization methods. MDPI 2023-08-24 /pmc/articles/PMC10536716/ /pubmed/37755174 http://dx.doi.org/10.3390/membranes13090752 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Charpentier, Lily A. Dolben, Emily F. Hendricks, Matthew R. Hogan, Deborah A. Bomberger, Jennifer M. Stanton, Bruce A. Bacterial Outer Membrane Vesicles and Immune Modulation of the Host |
title | Bacterial Outer Membrane Vesicles and Immune Modulation of the Host |
title_full | Bacterial Outer Membrane Vesicles and Immune Modulation of the Host |
title_fullStr | Bacterial Outer Membrane Vesicles and Immune Modulation of the Host |
title_full_unstemmed | Bacterial Outer Membrane Vesicles and Immune Modulation of the Host |
title_short | Bacterial Outer Membrane Vesicles and Immune Modulation of the Host |
title_sort | bacterial outer membrane vesicles and immune modulation of the host |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536716/ https://www.ncbi.nlm.nih.gov/pubmed/37755174 http://dx.doi.org/10.3390/membranes13090752 |
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