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Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model

BACKGROUND: Recently, natural killer (NK) cells emerged as a treatment option for various solid tumors. However, the immunosuppressive tumor immune microenvironment (TIME) can reduce the cytotoxic ability of NK cells in pancreatic ductal adenocarcinoma. Cancer-associated fibroblasts within the tumor...

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Detalles Bibliográficos
Autores principales:	Kim, Hyun-Ah, Kim, Hyunsoo, Nam, Min-Kyung, Park, Jong Kook, Lee, Moo-Yeal, Chung, Seok, Lee, Kyung-Mi, Kuh, Hyo-Jeong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536815/ https://www.ncbi.nlm.nih.gov/pubmed/37759302 http://dx.doi.org/10.1186/s12935-023-03064-9

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