Cargando…

Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review

Persistent Organic Pollutants (POPs) such as dichlorodimethyltrichloroethane (DDT) are present and ubiquitous in the environment due to their resilient nature. DDT is a prevalent endocrine disruptor still found in detectable amounts in organisms and the environment even after its use was banned in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Syed, Shermeen, Qasim, Shandana, Ejaz, Maheen, Sammar, Khan, Nimra, Ali, Haider, Zaker, Himasadat, Hatzidaki, Eleftheria, Mamoulakis, Charalampos, Tsatsakis, Aristidis, Shah, Syed Tahir Abbas, Amir, Saira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536953/
https://www.ncbi.nlm.nih.gov/pubmed/37755736
http://dx.doi.org/10.3390/toxics11090725
_version_ 1785112989554180096
author Syed, Shermeen
Qasim, Shandana
Ejaz, Maheen
Sammar
Khan, Nimra
Ali, Haider
Zaker, Himasadat
Hatzidaki, Eleftheria
Mamoulakis, Charalampos
Tsatsakis, Aristidis
Shah, Syed Tahir Abbas
Amir, Saira
author_facet Syed, Shermeen
Qasim, Shandana
Ejaz, Maheen
Sammar
Khan, Nimra
Ali, Haider
Zaker, Himasadat
Hatzidaki, Eleftheria
Mamoulakis, Charalampos
Tsatsakis, Aristidis
Shah, Syed Tahir Abbas
Amir, Saira
author_sort Syed, Shermeen
collection PubMed
description Persistent Organic Pollutants (POPs) such as dichlorodimethyltrichloroethane (DDT) are present and ubiquitous in the environment due to their resilient nature. DDT is a prevalent endocrine disruptor still found in detectable amounts in organisms and the environment even after its use was banned in the 1970s. Medline and Google Scholar were systematically searched to detect all relevant animal and human studies published in the last 20 years (January 2003 to February 2023) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In total, 38 studies were included for qualitative synthesis. This systematic search and review indicated that exposure to DDT is associated with female reproductive health issues, such as reduced fecundability; increased risk of preterm/premature deliveries; increased periods of gestation; alterations in the synthesis of crucial reproductive hormones (Progesterone and Oxytocin) through ion imbalances and changes in prostaglandin synthesis, myometrial and stromal hypertrophy, and edema; and variations in uterine contractions through increased uterine wet weight. There was also limited evidence indicating DDT as a carcinogen sufficient to instigate reproductive cancers. However, this review only takes into account the in vitro studies that have established a possible pathway to understand how DDT impacts female infertility and leads to reproductive cancers. Links between the pathways described in various studies have been developed in this review to produce a summarized picture of how one event might lead to another. Additionally, epidemiological studies that specifically targeted the exposure to DDT of females belonging to various ethnicities have been reviewed to develop an overall picture of prevailing female reproductive health concerns in different nations.
format Online
Article
Text
id pubmed-10536953
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105369532023-09-29 Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review Syed, Shermeen Qasim, Shandana Ejaz, Maheen Sammar Khan, Nimra Ali, Haider Zaker, Himasadat Hatzidaki, Eleftheria Mamoulakis, Charalampos Tsatsakis, Aristidis Shah, Syed Tahir Abbas Amir, Saira Toxics Review Persistent Organic Pollutants (POPs) such as dichlorodimethyltrichloroethane (DDT) are present and ubiquitous in the environment due to their resilient nature. DDT is a prevalent endocrine disruptor still found in detectable amounts in organisms and the environment even after its use was banned in the 1970s. Medline and Google Scholar were systematically searched to detect all relevant animal and human studies published in the last 20 years (January 2003 to February 2023) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In total, 38 studies were included for qualitative synthesis. This systematic search and review indicated that exposure to DDT is associated with female reproductive health issues, such as reduced fecundability; increased risk of preterm/premature deliveries; increased periods of gestation; alterations in the synthesis of crucial reproductive hormones (Progesterone and Oxytocin) through ion imbalances and changes in prostaglandin synthesis, myometrial and stromal hypertrophy, and edema; and variations in uterine contractions through increased uterine wet weight. There was also limited evidence indicating DDT as a carcinogen sufficient to instigate reproductive cancers. However, this review only takes into account the in vitro studies that have established a possible pathway to understand how DDT impacts female infertility and leads to reproductive cancers. Links between the pathways described in various studies have been developed in this review to produce a summarized picture of how one event might lead to another. Additionally, epidemiological studies that specifically targeted the exposure to DDT of females belonging to various ethnicities have been reviewed to develop an overall picture of prevailing female reproductive health concerns in different nations. MDPI 2023-08-24 /pmc/articles/PMC10536953/ /pubmed/37755736 http://dx.doi.org/10.3390/toxics11090725 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Syed, Shermeen
Qasim, Shandana
Ejaz, Maheen
Sammar
Khan, Nimra
Ali, Haider
Zaker, Himasadat
Hatzidaki, Eleftheria
Mamoulakis, Charalampos
Tsatsakis, Aristidis
Shah, Syed Tahir Abbas
Amir, Saira
Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review
title Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review
title_full Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review
title_fullStr Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review
title_full_unstemmed Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review
title_short Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review
title_sort effects of dichlorodiphenyltrichloroethane on the female reproductive tract leading to infertility and cancer: systematic search and review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536953/
https://www.ncbi.nlm.nih.gov/pubmed/37755736
http://dx.doi.org/10.3390/toxics11090725
work_keys_str_mv AT syedshermeen effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT qasimshandana effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT ejazmaheen effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT sammar effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT khannimra effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT alihaider effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT zakerhimasadat effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT hatzidakieleftheria effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT mamoulakischaralampos effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT tsatsakisaristidis effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT shahsyedtahirabbas effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview
AT amirsaira effectsofdichlorodiphenyltrichloroethaneonthefemalereproductivetractleadingtoinfertilityandcancersystematicsearchandreview