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The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting
Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536954/ https://www.ncbi.nlm.nih.gov/pubmed/37764025 http://dx.doi.org/10.3390/microorganisms11092182 |
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author | Metafuni, Elisabetta Di Marino, Luca Giammarco, Sabrina Bellesi, Silvia Limongiello, Maria Assunta Sorà, Federica Frioni, Filippo Maggi, Roberto Chiusolo, Patrizia Sica, Simona |
author_facet | Metafuni, Elisabetta Di Marino, Luca Giammarco, Sabrina Bellesi, Silvia Limongiello, Maria Assunta Sorà, Federica Frioni, Filippo Maggi, Roberto Chiusolo, Patrizia Sica, Simona |
author_sort | Metafuni, Elisabetta |
collection | PubMed |
description | Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current knowledge about the close link between microbiota and allogeneic stem cell transplantation setting. The PubMed search engine was used to perform this review. We analyzed data on microbiota dysbiosis related to the above-mentioned affecting factors. We also looked at treatments aimed at modifying gut dysbiosis and applications of fecal microbiota transplantation in the allogeneic stem cell transplant field, with particular interest in fecal microbiota transplantation for graft-versus-host disease (GvHD), multidrug-resistant and clostridium difficile infections, and microbiota restoration after chemotherapy and antibiotic therapy. |
format | Online Article Text |
id | pubmed-10536954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105369542023-09-29 The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting Metafuni, Elisabetta Di Marino, Luca Giammarco, Sabrina Bellesi, Silvia Limongiello, Maria Assunta Sorà, Federica Frioni, Filippo Maggi, Roberto Chiusolo, Patrizia Sica, Simona Microorganisms Review Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current knowledge about the close link between microbiota and allogeneic stem cell transplantation setting. The PubMed search engine was used to perform this review. We analyzed data on microbiota dysbiosis related to the above-mentioned affecting factors. We also looked at treatments aimed at modifying gut dysbiosis and applications of fecal microbiota transplantation in the allogeneic stem cell transplant field, with particular interest in fecal microbiota transplantation for graft-versus-host disease (GvHD), multidrug-resistant and clostridium difficile infections, and microbiota restoration after chemotherapy and antibiotic therapy. MDPI 2023-08-29 /pmc/articles/PMC10536954/ /pubmed/37764025 http://dx.doi.org/10.3390/microorganisms11092182 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Metafuni, Elisabetta Di Marino, Luca Giammarco, Sabrina Bellesi, Silvia Limongiello, Maria Assunta Sorà, Federica Frioni, Filippo Maggi, Roberto Chiusolo, Patrizia Sica, Simona The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting |
title | The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting |
title_full | The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting |
title_fullStr | The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting |
title_full_unstemmed | The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting |
title_short | The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting |
title_sort | role of fecal microbiota transplantation in the allogeneic stem cell transplant setting |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536954/ https://www.ncbi.nlm.nih.gov/pubmed/37764025 http://dx.doi.org/10.3390/microorganisms11092182 |
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