Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols

Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain im...

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Autores principales: Carresi, Cristina, Cardamone, Antonio, Coppoletta, Anna Rita, Mollace, Annachiara, Musolino, Vincenzo, Gliozzi, Micaela, Mollace, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536961/
https://www.ncbi.nlm.nih.gov/pubmed/37780094
http://dx.doi.org/10.3389/fnint.2023.1271005
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author Carresi, Cristina
Cardamone, Antonio
Coppoletta, Anna Rita
Mollace, Annachiara
Musolino, Vincenzo
Gliozzi, Micaela
Mollace, Vincenzo
author_facet Carresi, Cristina
Cardamone, Antonio
Coppoletta, Anna Rita
Mollace, Annachiara
Musolino, Vincenzo
Gliozzi, Micaela
Mollace, Vincenzo
author_sort Carresi, Cristina
collection PubMed
description Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain impairment. The relationship among hypertension, modulation of brain metabolite levels and cerebral diseases is of recent investigation, leaving many unanswered questions regarding the origin and consequences of the metabolic damage caused in grey and white matter during hypertension. Here we provide evidence for the influence of hypertension on NAA and Cho ratios in hypertensive rat thalamus and how the use of natural occurring compounds ameliorates the balance of thalamic metabolites.
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spelling pubmed-105369612023-09-29 Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols Carresi, Cristina Cardamone, Antonio Coppoletta, Anna Rita Mollace, Annachiara Musolino, Vincenzo Gliozzi, Micaela Mollace, Vincenzo Front Integr Neurosci Neuroscience Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain impairment. The relationship among hypertension, modulation of brain metabolite levels and cerebral diseases is of recent investigation, leaving many unanswered questions regarding the origin and consequences of the metabolic damage caused in grey and white matter during hypertension. Here we provide evidence for the influence of hypertension on NAA and Cho ratios in hypertensive rat thalamus and how the use of natural occurring compounds ameliorates the balance of thalamic metabolites. Frontiers Media S.A. 2023-09-14 /pmc/articles/PMC10536961/ /pubmed/37780094 http://dx.doi.org/10.3389/fnint.2023.1271005 Text en Copyright © 2023 Carresi, Cardamone, Coppoletta, Mollace, Musolino, Gliozzi and Mollace. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Carresi, Cristina
Cardamone, Antonio
Coppoletta, Anna Rita
Mollace, Annachiara
Musolino, Vincenzo
Gliozzi, Micaela
Mollace, Vincenzo
Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols
title Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols
title_full Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols
title_fullStr Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols
title_full_unstemmed Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols
title_short Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols
title_sort imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536961/
https://www.ncbi.nlm.nih.gov/pubmed/37780094
http://dx.doi.org/10.3389/fnint.2023.1271005
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