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Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves

This study aimed to evaluate by wide-expression profile analysis how early weaning at 120 days can alter the skeletal muscle metabolism of calves supplemented with a concentrated diet until the growth phase. Longissimus thoracis muscle samples were obtained by biopsy from two groups of calves, early...

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Autores principales: Pedro, Ariane Enara, Torrecilhas, Juliana Akamine, Torres, Rodrigo Nazaré Santos, Ramírez-Zamudio, Germán Darío, Baldassini, Welder Angelo, Chardulo, Luis Artur Loyola, Curi, Rogério Abdallah, Russo, Gustavo Henrique, Napolitano, Juliane Arielly, Bezerra Tinoco, Gustavo Lucas, Mariano, Thiago Barcaça, Caixeta, Jordana Luiza, Moriel, Philipe, Pereira, Guilherme Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536964/
https://www.ncbi.nlm.nih.gov/pubmed/37755308
http://dx.doi.org/10.3390/metabo13091028
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author Pedro, Ariane Enara
Torrecilhas, Juliana Akamine
Torres, Rodrigo Nazaré Santos
Ramírez-Zamudio, Germán Darío
Baldassini, Welder Angelo
Chardulo, Luis Artur Loyola
Curi, Rogério Abdallah
Russo, Gustavo Henrique
Napolitano, Juliane Arielly
Bezerra Tinoco, Gustavo Lucas
Mariano, Thiago Barcaça
Caixeta, Jordana Luiza
Moriel, Philipe
Pereira, Guilherme Luis
author_facet Pedro, Ariane Enara
Torrecilhas, Juliana Akamine
Torres, Rodrigo Nazaré Santos
Ramírez-Zamudio, Germán Darío
Baldassini, Welder Angelo
Chardulo, Luis Artur Loyola
Curi, Rogério Abdallah
Russo, Gustavo Henrique
Napolitano, Juliane Arielly
Bezerra Tinoco, Gustavo Lucas
Mariano, Thiago Barcaça
Caixeta, Jordana Luiza
Moriel, Philipe
Pereira, Guilherme Luis
author_sort Pedro, Ariane Enara
collection PubMed
description This study aimed to evaluate by wide-expression profile analysis how early weaning at 120 days can alter the skeletal muscle metabolism of calves supplemented with a concentrated diet until the growth phase. Longissimus thoracis muscle samples were obtained by biopsy from two groups of calves, early weaned (EW; n = 8) and conventionally weaned (CW; n = 8) at two different times (120 days of age—T1 [EW] and 205 days of age—T2 [CW]). Next, differential gene expression analysis and functional enrichment of metabolic pathways and biological processes were performed. The results showed respectively 658 and 165 differentially expressed genes when T1 and T2 were contrasted in the early weaning group and when early and conventionally weaned groups were compared at T2. The FABP4, SCD1, FASN, LDLR, ADIPOQ, ACACA, PPARD, and ACOX3 genes were prospected in both comparisons described above. Given the key role of these differentially expressed genes in lipid and fatty acid metabolism, the results demonstrate the effect of diet on the modulation of energy metabolism, particularly favoring postnatal adipogenesis and lipogenesis, as well as a consequent trend in obtaining better quality cuts, as long as an environment for the maintenance of these alterations until adulthood is provided.
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spelling pubmed-105369642023-09-29 Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves Pedro, Ariane Enara Torrecilhas, Juliana Akamine Torres, Rodrigo Nazaré Santos Ramírez-Zamudio, Germán Darío Baldassini, Welder Angelo Chardulo, Luis Artur Loyola Curi, Rogério Abdallah Russo, Gustavo Henrique Napolitano, Juliane Arielly Bezerra Tinoco, Gustavo Lucas Mariano, Thiago Barcaça Caixeta, Jordana Luiza Moriel, Philipe Pereira, Guilherme Luis Metabolites Article This study aimed to evaluate by wide-expression profile analysis how early weaning at 120 days can alter the skeletal muscle metabolism of calves supplemented with a concentrated diet until the growth phase. Longissimus thoracis muscle samples were obtained by biopsy from two groups of calves, early weaned (EW; n = 8) and conventionally weaned (CW; n = 8) at two different times (120 days of age—T1 [EW] and 205 days of age—T2 [CW]). Next, differential gene expression analysis and functional enrichment of metabolic pathways and biological processes were performed. The results showed respectively 658 and 165 differentially expressed genes when T1 and T2 were contrasted in the early weaning group and when early and conventionally weaned groups were compared at T2. The FABP4, SCD1, FASN, LDLR, ADIPOQ, ACACA, PPARD, and ACOX3 genes were prospected in both comparisons described above. Given the key role of these differentially expressed genes in lipid and fatty acid metabolism, the results demonstrate the effect of diet on the modulation of energy metabolism, particularly favoring postnatal adipogenesis and lipogenesis, as well as a consequent trend in obtaining better quality cuts, as long as an environment for the maintenance of these alterations until adulthood is provided. MDPI 2023-09-21 /pmc/articles/PMC10536964/ /pubmed/37755308 http://dx.doi.org/10.3390/metabo13091028 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pedro, Ariane Enara
Torrecilhas, Juliana Akamine
Torres, Rodrigo Nazaré Santos
Ramírez-Zamudio, Germán Darío
Baldassini, Welder Angelo
Chardulo, Luis Artur Loyola
Curi, Rogério Abdallah
Russo, Gustavo Henrique
Napolitano, Juliane Arielly
Bezerra Tinoco, Gustavo Lucas
Mariano, Thiago Barcaça
Caixeta, Jordana Luiza
Moriel, Philipe
Pereira, Guilherme Luis
Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves
title Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves
title_full Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves
title_fullStr Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves
title_full_unstemmed Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves
title_short Early Weaning Possibly Increases the Activity of Lipogenic and Adipogenic Pathways in Intramuscular Adipose Tissue of Nellore Calves
title_sort early weaning possibly increases the activity of lipogenic and adipogenic pathways in intramuscular adipose tissue of nellore calves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536964/
https://www.ncbi.nlm.nih.gov/pubmed/37755308
http://dx.doi.org/10.3390/metabo13091028
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