Single-Dose Intranasal Immunisation with Novel Chimeric H1N1 Expressing the Receptor-Binding Domain of SARS-CoV-2 Induces Robust Mucosal Immunity, Tissue-Resident Memory T Cells, and Heterologous Protection in Mice

Current COVID-19 vaccines can effectively reduce disease severity and hospitalisation; however, they are not considerably effective in preventing infection and transmission. In this context, mucosal vaccines are pertinent to prevent SARS-CoV-2 infection and spread. In this study, we generated a repl...

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Detalles Bibliográficos
Autores principales: Wang, Donghong, Deng, Yao, Zhou, Jianfang, Wang, Wen, Huang, Baoying, Wang, Wenling, Wei, Lan, Ren, Jiao, Han, Ruiwen, Bing, Jialuo, Zhai, Chengcheng, Guo, Xiaoyan, Tan, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537001/
https://www.ncbi.nlm.nih.gov/pubmed/37766130
http://dx.doi.org/10.3390/vaccines11091453

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