Cargando…
3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering
Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO(2) laser for the manufacturing of carvedilol personalised dosage forms of v...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537056/ https://www.ncbi.nlm.nih.gov/pubmed/37765199 http://dx.doi.org/10.3390/pharmaceutics15092230 |
_version_ | 1785113013313863680 |
---|---|
author | Tabriz, Atabak Ghanizadeh Gonot-Munck, Quentin Baudoux, Arnaud Garg, Vivek Farnish, Richard Katsamenis, Orestis L. Hui, Ho-Wah Boersen, Nathan Roberts, Sandra Jones, John Douroumis, Dennis |
author_facet | Tabriz, Atabak Ghanizadeh Gonot-Munck, Quentin Baudoux, Arnaud Garg, Vivek Farnish, Richard Katsamenis, Orestis L. Hui, Ho-Wah Boersen, Nathan Roberts, Sandra Jones, John Douroumis, Dennis |
author_sort | Tabriz, Atabak Ghanizadeh |
collection | PubMed |
description | Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO(2) laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO(2) intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs. |
format | Online Article Text |
id | pubmed-10537056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105370562023-09-29 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering Tabriz, Atabak Ghanizadeh Gonot-Munck, Quentin Baudoux, Arnaud Garg, Vivek Farnish, Richard Katsamenis, Orestis L. Hui, Ho-Wah Boersen, Nathan Roberts, Sandra Jones, John Douroumis, Dennis Pharmaceutics Article Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO(2) laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO(2) intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs. MDPI 2023-08-29 /pmc/articles/PMC10537056/ /pubmed/37765199 http://dx.doi.org/10.3390/pharmaceutics15092230 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tabriz, Atabak Ghanizadeh Gonot-Munck, Quentin Baudoux, Arnaud Garg, Vivek Farnish, Richard Katsamenis, Orestis L. Hui, Ho-Wah Boersen, Nathan Roberts, Sandra Jones, John Douroumis, Dennis 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering |
title | 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering |
title_full | 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering |
title_fullStr | 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering |
title_full_unstemmed | 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering |
title_short | 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering |
title_sort | 3d printing of personalised carvedilol tablets using selective laser sintering |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537056/ https://www.ncbi.nlm.nih.gov/pubmed/37765199 http://dx.doi.org/10.3390/pharmaceutics15092230 |
work_keys_str_mv | AT tabrizatabakghanizadeh 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT gonotmunckquentin 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT baudouxarnaud 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT gargvivek 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT farnishrichard 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT katsamenisorestisl 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT huihowah 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT boersennathan 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT robertssandra 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT jonesjohn 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering AT douroumisdennis 3dprintingofpersonalisedcarvediloltabletsusingselectivelasersintering |