The critical role of platelet in cancer progression and metastasis

Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate (ADP) or extracellular matrix (ECM) can activate these small particles that function in hemostasis and thrombosis. Moreover, platelets induce Epithelial...

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Autores principales: Zhou, Lin, Zhang, Zhe, Tian, Yizhou, Li, Zefei, Liu, Zhongliang, Zhu, Sibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537080/
https://www.ncbi.nlm.nih.gov/pubmed/37770941
http://dx.doi.org/10.1186/s40001-023-01342-w
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author Zhou, Lin
Zhang, Zhe
Tian, Yizhou
Li, Zefei
Liu, Zhongliang
Zhu, Sibo
author_facet Zhou, Lin
Zhang, Zhe
Tian, Yizhou
Li, Zefei
Liu, Zhongliang
Zhu, Sibo
author_sort Zhou, Lin
collection PubMed
description Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate (ADP) or extracellular matrix (ECM) can activate these small particles that function in hemostasis and thrombosis. Moreover, platelets induce Epithelial Mesenchymal Transition (EMT) to promote cancer progression and invasiveness. The activated platelets protect circulating tumor cells from immune surveillance and anoikis. They also mediate tumor cell arrest, extravasation and angiogenesis in distant organs through direct or indirect modulation, creating a metastatic microenvironment. This review summarizes the recent advances and progress of mechanisms in platelet activation and its interaction with cancer cells in metastasis.
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spelling pubmed-105370802023-09-29 The critical role of platelet in cancer progression and metastasis Zhou, Lin Zhang, Zhe Tian, Yizhou Li, Zefei Liu, Zhongliang Zhu, Sibo Eur J Med Res Review Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate (ADP) or extracellular matrix (ECM) can activate these small particles that function in hemostasis and thrombosis. Moreover, platelets induce Epithelial Mesenchymal Transition (EMT) to promote cancer progression and invasiveness. The activated platelets protect circulating tumor cells from immune surveillance and anoikis. They also mediate tumor cell arrest, extravasation and angiogenesis in distant organs through direct or indirect modulation, creating a metastatic microenvironment. This review summarizes the recent advances and progress of mechanisms in platelet activation and its interaction with cancer cells in metastasis. BioMed Central 2023-09-28 /pmc/articles/PMC10537080/ /pubmed/37770941 http://dx.doi.org/10.1186/s40001-023-01342-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhou, Lin
Zhang, Zhe
Tian, Yizhou
Li, Zefei
Liu, Zhongliang
Zhu, Sibo
The critical role of platelet in cancer progression and metastasis
title The critical role of platelet in cancer progression and metastasis
title_full The critical role of platelet in cancer progression and metastasis
title_fullStr The critical role of platelet in cancer progression and metastasis
title_full_unstemmed The critical role of platelet in cancer progression and metastasis
title_short The critical role of platelet in cancer progression and metastasis
title_sort critical role of platelet in cancer progression and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537080/
https://www.ncbi.nlm.nih.gov/pubmed/37770941
http://dx.doi.org/10.1186/s40001-023-01342-w
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