Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival

Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Santonja, Carlos, Morillo-Giles, Daniel, Prieto-Pareja, Elena, Soto-de Ozaeta, Carlos, Serrano-del Castillo, Cristina, Salgado-Sánchez, Rocío, Yi-Shi, Ana-Wu-Yang, Manso, Rebeca, Rodríguez-Pinilla, Socorro María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537167/
https://www.ncbi.nlm.nih.gov/pubmed/37763746
http://dx.doi.org/10.3390/medicina59091628
_version_ 1785113039640461312
author Santonja, Carlos
Morillo-Giles, Daniel
Prieto-Pareja, Elena
Soto-de Ozaeta, Carlos
Serrano-del Castillo, Cristina
Salgado-Sánchez, Rocío
Yi-Shi, Ana-Wu-Yang
Manso, Rebeca
Rodríguez-Pinilla, Socorro María
author_facet Santonja, Carlos
Morillo-Giles, Daniel
Prieto-Pareja, Elena
Soto-de Ozaeta, Carlos
Serrano-del Castillo, Cristina
Salgado-Sánchez, Rocío
Yi-Shi, Ana-Wu-Yang
Manso, Rebeca
Rodríguez-Pinilla, Socorro María
author_sort Santonja, Carlos
collection PubMed
description Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positive ALCL with 9-year survival in a young woman who was treated upfront with corticosteroids and standard chemotherapy, and review thoroughly the previously published cases. Such an unexpected, good outcome hints at the existence of different clinical subgroups in the leukaemic variant of ALK-positive ALCL.
format Online
Article
Text
id pubmed-10537167
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105371672023-09-29 Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival Santonja, Carlos Morillo-Giles, Daniel Prieto-Pareja, Elena Soto-de Ozaeta, Carlos Serrano-del Castillo, Cristina Salgado-Sánchez, Rocío Yi-Shi, Ana-Wu-Yang Manso, Rebeca Rodríguez-Pinilla, Socorro María Medicina (Kaunas) Case Report Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positive ALCL with 9-year survival in a young woman who was treated upfront with corticosteroids and standard chemotherapy, and review thoroughly the previously published cases. Such an unexpected, good outcome hints at the existence of different clinical subgroups in the leukaemic variant of ALK-positive ALCL. MDPI 2023-09-08 /pmc/articles/PMC10537167/ /pubmed/37763746 http://dx.doi.org/10.3390/medicina59091628 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Santonja, Carlos
Morillo-Giles, Daniel
Prieto-Pareja, Elena
Soto-de Ozaeta, Carlos
Serrano-del Castillo, Cristina
Salgado-Sánchez, Rocío
Yi-Shi, Ana-Wu-Yang
Manso, Rebeca
Rodríguez-Pinilla, Socorro María
Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival
title Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival
title_full Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival
title_fullStr Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival
title_full_unstemmed Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival
title_short Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival
title_sort leukaemic presentation of small-cell alk-positive anaplastic large cell lymphoma in a young woman—report of a case with 9-year survival
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537167/
https://www.ncbi.nlm.nih.gov/pubmed/37763746
http://dx.doi.org/10.3390/medicina59091628
work_keys_str_mv AT santonjacarlos leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT morillogilesdaniel leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT prietoparejaelena leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT sotodeozaetacarlos leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT serranodelcastillocristina leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT salgadosanchezrocio leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT yishianawuyang leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT mansorebeca leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival
AT rodriguezpinillasocorromaria leukaemicpresentationofsmallcellalkpositiveanaplasticlargecelllymphomainayoungwomanreportofacasewith9yearsurvival

Ejemplares similares