Cargando…

EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma

This study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning were performed in three microarray datasets (GSE2371, GS...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Tengteng, Zhang, Yuanbin, Ren, Zhixuan, Cong, Ying, Long, Jingyi, Peng, Manli, Faleti, Oluwasijibomi Damola, Yang, Yinggui, Li, Xin, Lyu, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537168/
https://www.ncbi.nlm.nih.gov/pubmed/37766321
http://dx.doi.org/10.3390/v15091915
_version_ 1785113039884779520
author Ding, Tengteng
Zhang, Yuanbin
Ren, Zhixuan
Cong, Ying
Long, Jingyi
Peng, Manli
Faleti, Oluwasijibomi Damola
Yang, Yinggui
Li, Xin
Lyu, Xiaoming
author_facet Ding, Tengteng
Zhang, Yuanbin
Ren, Zhixuan
Cong, Ying
Long, Jingyi
Peng, Manli
Faleti, Oluwasijibomi Damola
Yang, Yinggui
Li, Xin
Lyu, Xiaoming
author_sort Ding, Tengteng
collection PubMed
description This study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning were performed in three microarray datasets (GSE2371, GSE12452, and GSE102349) collected from the GEO database. Three hundred and sixty-six EBV-DEGs were identified, 25 of which were found to be significantly associated with NPC prognosis. These 25 genes were used to classify NPC into two subtypes, and six genes (C16orf54, CD27, CD53, CRIP1, RARRES3, and TBC1D10C) were found to be hub genes in NPC related to immune infiltration and cell cycle regulation. It was shown that these genes could be used to predict the prognosis of NPC, with functions related to tumor proliferation and immune infiltration, making them potential therapeutic targets. The findings of this study could aid in the development of screening and prognostic methods for NPC based on EBV-related features.
format Online
Article
Text
id pubmed-10537168
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105371682023-09-29 EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma Ding, Tengteng Zhang, Yuanbin Ren, Zhixuan Cong, Ying Long, Jingyi Peng, Manli Faleti, Oluwasijibomi Damola Yang, Yinggui Li, Xin Lyu, Xiaoming Viruses Article This study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning were performed in three microarray datasets (GSE2371, GSE12452, and GSE102349) collected from the GEO database. Three hundred and sixty-six EBV-DEGs were identified, 25 of which were found to be significantly associated with NPC prognosis. These 25 genes were used to classify NPC into two subtypes, and six genes (C16orf54, CD27, CD53, CRIP1, RARRES3, and TBC1D10C) were found to be hub genes in NPC related to immune infiltration and cell cycle regulation. It was shown that these genes could be used to predict the prognosis of NPC, with functions related to tumor proliferation and immune infiltration, making them potential therapeutic targets. The findings of this study could aid in the development of screening and prognostic methods for NPC based on EBV-related features. MDPI 2023-09-12 /pmc/articles/PMC10537168/ /pubmed/37766321 http://dx.doi.org/10.3390/v15091915 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ding, Tengteng
Zhang, Yuanbin
Ren, Zhixuan
Cong, Ying
Long, Jingyi
Peng, Manli
Faleti, Oluwasijibomi Damola
Yang, Yinggui
Li, Xin
Lyu, Xiaoming
EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma
title EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma
title_full EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma
title_fullStr EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma
title_full_unstemmed EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma
title_short EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma
title_sort ebv-associated hub genes as potential biomarkers for predicting the prognosis of nasopharyngeal carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537168/
https://www.ncbi.nlm.nih.gov/pubmed/37766321
http://dx.doi.org/10.3390/v15091915
work_keys_str_mv AT dingtengteng ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT zhangyuanbin ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT renzhixuan ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT congying ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT longjingyi ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT pengmanli ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT faletioluwasijibomidamola ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT yangyinggui ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT lixin ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma
AT lyuxiaoming ebvassociatedhubgenesaspotentialbiomarkersforpredictingtheprognosisofnasopharyngealcarcinoma