The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

BACKGROUND: RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R) instead of the exonically encoded GluA2(Q). Reduced Q/R site editing increases AMPA receptor calcium permeability and leads to dendritic spine loss, neur...

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Detalles Bibliográficos
Autores principales: Wright, Amanda L., Konen, Lyndsey M., Mockett, Bruce G., Morris, Gary P., Singh, Anurag, Burbano, Lisseth Estefania, Milham, Luke, Hoang, Monica, Zinn, Raphael, Chesworth, Rose, Tan, Richard P., Royle, Gordon A., Clark, Ian, Petrou, Steven, Abraham, Wickliffe C., Vissel, Bryce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537207/
https://www.ncbi.nlm.nih.gov/pubmed/37759260
http://dx.doi.org/10.1186/s13024-023-00632-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537207/
https://www.ncbi.nlm.nih.gov/pubmed/37759260
http://dx.doi.org/10.1186/s13024-023-00632-5

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