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Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair

In recent years, bone tissue engineering (BTE) has played an essential role in the repair of bone tissue defects. Although bioactive factors as one component of BTE have great potential to effectively promote cell differentiation and bone regeneration, they are usually not used alone due to their sh...

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Autores principales: Pei, Baoqing, Hu, Mengyuan, Wu, Xueqing, Lu, Da, Zhang, Shijia, Zhang, Le, Wu, Shuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537235/
https://www.ncbi.nlm.nih.gov/pubmed/37781533
http://dx.doi.org/10.3389/fbioe.2023.1230682
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author Pei, Baoqing
Hu, Mengyuan
Wu, Xueqing
Lu, Da
Zhang, Shijia
Zhang, Le
Wu, Shuqin
author_facet Pei, Baoqing
Hu, Mengyuan
Wu, Xueqing
Lu, Da
Zhang, Shijia
Zhang, Le
Wu, Shuqin
author_sort Pei, Baoqing
collection PubMed
description In recent years, bone tissue engineering (BTE) has played an essential role in the repair of bone tissue defects. Although bioactive factors as one component of BTE have great potential to effectively promote cell differentiation and bone regeneration, they are usually not used alone due to their short effective half-lives, high concentrations, etc. The release rate of bioactive factors could be controlled by loading them into scaffolds, and the scaffold microstructure has been shown to significantly influence release rates of bioactive factors. Therefore, this review attempted to investigate how the scaffold microstructure affected the release rate of bioactive factors, in which the variables included pore size, pore shape and porosity. The loading nature and the releasing mechanism of bioactive factors were also summarized. The main conclusions were achieved as follows: i) The pore shapes in the scaffold may have had no apparent effect on the release of bioactive factors but significantly affected mechanical properties of the scaffolds; ii) The pore size of about 400 μm in the scaffold may be more conducive to controlling the release of bioactive factors to promote bone formation; iii) The porosity of scaffolds may be positively correlated with the release rate, and the porosity of 70%–80% may be better to control the release rate. This review indicates that a slow-release system with proper scaffold microstructure control could be a tremendous inspiration for developing new treatment strategies for bone disease. It is anticipated to eventually be developed into clinical applications to tackle treatment-related issues effectively.
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spelling pubmed-105372352023-09-29 Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair Pei, Baoqing Hu, Mengyuan Wu, Xueqing Lu, Da Zhang, Shijia Zhang, Le Wu, Shuqin Front Bioeng Biotechnol Bioengineering and Biotechnology In recent years, bone tissue engineering (BTE) has played an essential role in the repair of bone tissue defects. Although bioactive factors as one component of BTE have great potential to effectively promote cell differentiation and bone regeneration, they are usually not used alone due to their short effective half-lives, high concentrations, etc. The release rate of bioactive factors could be controlled by loading them into scaffolds, and the scaffold microstructure has been shown to significantly influence release rates of bioactive factors. Therefore, this review attempted to investigate how the scaffold microstructure affected the release rate of bioactive factors, in which the variables included pore size, pore shape and porosity. The loading nature and the releasing mechanism of bioactive factors were also summarized. The main conclusions were achieved as follows: i) The pore shapes in the scaffold may have had no apparent effect on the release of bioactive factors but significantly affected mechanical properties of the scaffolds; ii) The pore size of about 400 μm in the scaffold may be more conducive to controlling the release of bioactive factors to promote bone formation; iii) The porosity of scaffolds may be positively correlated with the release rate, and the porosity of 70%–80% may be better to control the release rate. This review indicates that a slow-release system with proper scaffold microstructure control could be a tremendous inspiration for developing new treatment strategies for bone disease. It is anticipated to eventually be developed into clinical applications to tackle treatment-related issues effectively. Frontiers Media S.A. 2023-09-14 /pmc/articles/PMC10537235/ /pubmed/37781533 http://dx.doi.org/10.3389/fbioe.2023.1230682 Text en Copyright © 2023 Pei, Hu, Wu, Lu, Zhang, Zhang and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Pei, Baoqing
Hu, Mengyuan
Wu, Xueqing
Lu, Da
Zhang, Shijia
Zhang, Le
Wu, Shuqin
Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair
title Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair
title_full Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair
title_fullStr Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair
title_full_unstemmed Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair
title_short Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair
title_sort investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537235/
https://www.ncbi.nlm.nih.gov/pubmed/37781533
http://dx.doi.org/10.3389/fbioe.2023.1230682
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