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Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults

Background. The evidence linking the use of household pesticides and the risk of lymphoma is scanty. Methods. We explored the hypothesis in a population-based case-control study on lymphoma conducted in Sardinia, Italy, in 1998–2004, including 325 cases and 465 population controls and data on lifeti...

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Autores principales: Cocco, Pierluigi, Satta, Giannina, Cancedda, Valerio, Meloni, Federico, Milia, Simone, Pilia, Ilaria, Zucca, Mariagrazia, De Matteis, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537294/
https://www.ncbi.nlm.nih.gov/pubmed/37755762
http://dx.doi.org/10.3390/toxics11090752
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author Cocco, Pierluigi
Satta, Giannina
Cancedda, Valerio
Meloni, Federico
Milia, Simone
Pilia, Ilaria
Zucca, Mariagrazia
De Matteis, Sara
author_facet Cocco, Pierluigi
Satta, Giannina
Cancedda, Valerio
Meloni, Federico
Milia, Simone
Pilia, Ilaria
Zucca, Mariagrazia
De Matteis, Sara
author_sort Cocco, Pierluigi
collection PubMed
description Background. The evidence linking the use of household pesticides and the risk of lymphoma is scanty. Methods. We explored the hypothesis in a population-based case-control study on lymphoma conducted in Sardinia, Italy, in 1998–2004, including 325 cases and 465 population controls and data on lifetime frequency, seasonality, and years of use of household insecticides and potential confounders. We calculated the risk of lymphoma (all subtypes) and its major subtypes associated with using household insecticides in three time windows (up to 1978, from 1979–2001, and 2002 onwards) with unconditional logistic regression adjusting by age, sex, education, and occupational exposure to pesticides. Results. Household insecticides did not increase risk of lymphoma (all subtypes), Hodgkin’s lymphoma, B-cell lymphoma, and the major B-cell lymphoma subtypes. The risk of multiple myeloma (MM) but not the other subtypes showed a non-significant upward trend (p = 0.203) with increasing quartiles of days of use in the time window when propoxur was the most popular household insecticide. Conclusions. Our results suggest no association between the household use of insecticides and the risk of lymphoma. Further studies are warranted to confirm or discard an association between MM risk and the use of propoxur.
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spelling pubmed-105372942023-09-29 Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults Cocco, Pierluigi Satta, Giannina Cancedda, Valerio Meloni, Federico Milia, Simone Pilia, Ilaria Zucca, Mariagrazia De Matteis, Sara Toxics Article Background. The evidence linking the use of household pesticides and the risk of lymphoma is scanty. Methods. We explored the hypothesis in a population-based case-control study on lymphoma conducted in Sardinia, Italy, in 1998–2004, including 325 cases and 465 population controls and data on lifetime frequency, seasonality, and years of use of household insecticides and potential confounders. We calculated the risk of lymphoma (all subtypes) and its major subtypes associated with using household insecticides in three time windows (up to 1978, from 1979–2001, and 2002 onwards) with unconditional logistic regression adjusting by age, sex, education, and occupational exposure to pesticides. Results. Household insecticides did not increase risk of lymphoma (all subtypes), Hodgkin’s lymphoma, B-cell lymphoma, and the major B-cell lymphoma subtypes. The risk of multiple myeloma (MM) but not the other subtypes showed a non-significant upward trend (p = 0.203) with increasing quartiles of days of use in the time window when propoxur was the most popular household insecticide. Conclusions. Our results suggest no association between the household use of insecticides and the risk of lymphoma. Further studies are warranted to confirm or discard an association between MM risk and the use of propoxur. MDPI 2023-09-05 /pmc/articles/PMC10537294/ /pubmed/37755762 http://dx.doi.org/10.3390/toxics11090752 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cocco, Pierluigi
Satta, Giannina
Cancedda, Valerio
Meloni, Federico
Milia, Simone
Pilia, Ilaria
Zucca, Mariagrazia
De Matteis, Sara
Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults
title Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults
title_full Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults
title_fullStr Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults
title_full_unstemmed Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults
title_short Is a Good Sleep on Mosquito-Free Nights Worth the Risk of Lymphoma Associated with the Use of Household Insecticides? A Case-Control Study of Lymphoma Subtypes in Adults
title_sort is a good sleep on mosquito-free nights worth the risk of lymphoma associated with the use of household insecticides? a case-control study of lymphoma subtypes in adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537294/
https://www.ncbi.nlm.nih.gov/pubmed/37755762
http://dx.doi.org/10.3390/toxics11090752
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