Cargando…

5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens

A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing of these compounds against pathogens of the ESKAPE panel showed a good activity of lead compound 1-(2-methoxyethyl)-5-(5-nitro-2-furoyl)-3-(...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rogacheva, Elizaveta, Kraeva, Lyudmila, Lukin, Alexey, Vinogradova, Lyubov, Komarova, Kristina, Chudinov, Mikhail, Gureev, Maxim, Chupakhin, Evgeny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537382/ https://www.ncbi.nlm.nih.gov/pubmed/37764267 http://dx.doi.org/10.3390/molecules28186491

Ejemplares similares

Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke–Blackburn–Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria
por: Sapegin, Alexander, et al.
Publicado: (2022)

Synthesis and Antibacterial Evaluation of Ciprofloxacin Congeners with Spirocyclic Amine Periphery
por: Lukin, Alexei, et al.
Publicado: (2023)

Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents
por: Lukin, Alexei, et al.
Publicado: (2022)

Periphery Exploration around 2,6-Diazaspiro[3.4]octane Core Identifies a Potent Nitrofuran Antitubercular Lead
por: Lukin, Alexei, et al.
Publicado: (2023)

Mutually Isomeric 2- and 4-(3-Nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens
por: Chuprun, Sergey, et al.
Publicado: (2020)

In-Vitro Antibacterial Activity of Curcumin-Loaded Nanofibers Based on Hyaluronic Acid against Multidrug-Resistant ESKAPE Pathogens
por: Snetkov, Petr, et al.
Publicado: (2022)

Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists
por: Lukin, Alexey, et al.
Publicado: (2021)

Discovery and In Vivo Efficacy of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 4-(2-Aminoethyl)-N-(3,5-dimethylphenyl)piperidine-1-carboxamide Hydrochloride (AP163) for the Treatment of Psychotic Disorders
por: Krasavin, Mikhail, et al.
Publicado: (2022)

Presence of nitrofurans and their metabolites in gelatine
por: O'Keeffe, Michael, et al.
Publicado: (2021)

Separation of motions and vibrational separation of fractions for biocide brass
por: Sabbouh, Mirna, et al.
Publicado: (2021)

New Method of Analysis of Nitrofurans and Nitrofuran Metabolites in Different Biological Matrices Using UHPLC-MS/MS
por: Śniegocki, Tomasz, et al.
Publicado: (2018)

Electron Attachment Studies with the Potential Radiosensitizer 2-Nitrofuran
por: Saqib, Muhammad, et al.
Publicado: (2020)

Ultrasensitive strips for the quadruple detection of nitrofuran metabolite residues
por: Wu, Wei, et al.
Publicado: (2019)

Synthesis and Evaluation of the Antifungal and Toxicological Activity of Nitrofuran Derivatives
por: Vaso, Carolina Orlando, et al.
Publicado: (2022)

Sonochemical fabrication of gradient antibacterial materials based on Cu-Zn alloy
por: Sabbouh, Mirna, et al.
Publicado: (2022)

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species
por: Zhou, Linna, et al.
Publicado: (2012)

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species
por: Zhou, Linna, et al.
Publicado: (2020)

Late-stage functionalization of 5-nitrofurans derivatives and their antibacterial activities
por: Chen, Geshuyi, et al.
Publicado: (2023)

Antibacterial and Osteogenic Properties of Ag Nanoparticles and Ag/TiO(2) Nanostructures Prepared by Atomic Layer Deposition
por: Nazarov, Denis, et al.
Publicado: (2022)

Spirocyclic Motifs in Natural Products
por: Chupakhin, Evgeny, et al.
Publicado: (2019)

New test for sensitivity evaluation of Trichomonas vaginalis to nitroimidazoles and nitrofurans in vitro
por: Makhlay, NS
Publicado: (2011)

Pentacyclic Nitrofurans with In Vivo Efficacy and Activity against Nonreplicating Mycobacterium tuberculosis
por: Rakesh,, et al.
Publicado: (2014)

Nitrofurans: Revival of an “old” drug class in the fight against antibiotic resistance
por: Le, Vuong Van Hung, et al.
Publicado: (2021)

Immunosensor of Nitrofuran Antibiotics and Their Metabolites in Animal-Derived Foods: A Review
por: Jia, Jingze, et al.
Publicado: (2022)

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens
por: Santajit, Sirijan, et al.
Publicado: (2016)

Investigating the OXA Variants of ESKAPE Pathogens
por: Pandey, Deeksha, et al.
Publicado: (2021)

Editorial: ESKAPE biofilm: challenges and solutions
por: Tiwari, Vishvanath
Publicado: (2023)

Conditions Under Which Glutathione Disrupts the Biofilms and Improves Antibiotic Efficacy of Both ESKAPE and Non-ESKAPE Species
por: Das, Theerthankar, et al.
Publicado: (2019)

Exploring Networks of Lexical Variation in Russian Sign Language
por: Kimmelman, Vadim, et al.
Publicado: (2022)

Eskape Infection Control: Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections (Adv. Sci. 1/2020)
por: Ma, Yu‐Xuan, et al.
Publicado: (2020)

In vitro synergy of 5-nitrofurans, vancomycin and sodium deoxycholate against Gram-negative pathogens
por: Olivera, Catrina, et al.
Publicado: (2021)

Exposure Assessment of Nitrofuran Metabolites in Fish and Honey Produced in Armenia: A Pilot Investigation
por: Pipoyan, Davit, et al.
Publicado: (2023)

Antimicrobial Activity of Gallium Compounds on ESKAPE Pathogens
por: Hijazi, Sarah, et al.
Publicado: (2018)

Are Antimicrobial Peptide Dendrimers an Escape from ESKAPE?
por: Kawano, Yayoi, et al.
Publicado: (2020)

A Novel Alkaliphilic Streptomyces Inhibits ESKAPE Pathogens
por: Terra, Luciana, et al.
Publicado: (2018)

Antibacterial activity of medicinal plants against ESKAPE: An update
por: Bhatia, Priya, et al.
Publicado: (2021)

ESKAPE and Beyond: The Burden of Coinfections in the COVID-19 Pandemic
por: Loyola-Cruz, Miguel Ángel, et al.
Publicado: (2023)

Discovery of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 2-(5-(4′-Chloro-[1,1′-biphenyl]-4-yl)-4H-1,2,4-triazol-3-yl)ethan-1-amine (LK00764) for the Treatment of Psychotic Disorders
por: Krasavin, Mikhail, et al.
Publicado: (2022)

Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic Escherichia coli Nitrofurantoin and Furazidin In Vitro Susceptibility Testing
por: Bielec, Filip, et al.
Publicado: (2023)

Hydrophobic carboxymethyl cellulose as a clean-up sorbent in the determination of nitrofuran metabolites in animal-fat samples
por: Thabet, Omar A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eh4bnifqbhef87eampe34r8jlo