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Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System

Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the mod...

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Autores principales: Crișan, Andrea Gabriela, Porfire, Alina, Iurian, Sonia, Rus, Lucia Maria, Lucăcel Ciceo, Raluca, Turza, Alexandru, Tomuță, Ioan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537489/
https://www.ncbi.nlm.nih.gov/pubmed/37765129
http://dx.doi.org/10.3390/ph16091321
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author Crișan, Andrea Gabriela
Porfire, Alina
Iurian, Sonia
Rus, Lucia Maria
Lucăcel Ciceo, Raluca
Turza, Alexandru
Tomuță, Ioan
author_facet Crișan, Andrea Gabriela
Porfire, Alina
Iurian, Sonia
Rus, Lucia Maria
Lucăcel Ciceo, Raluca
Turza, Alexandru
Tomuță, Ioan
author_sort Crișan, Andrea Gabriela
collection PubMed
description Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the modulation of drug release profiles is crucial to ensure the superior efficacy and safety of modern 3D-printed medications compared to those of conventional ones. Our work aims to solidify the groundwork for the preparation of 3D-printed tablets that ensure the sustained release of diclofenac sodium. Specifically, we achieved the fast release of a diclofenac sodium dose to allow for the prompt onset of its pharmacological effect, further sustaining by the slow release of another dose to maintain the effect over a prolonged timeframe. In this regard, proper formulation and design strategies (a honeycomb structure for the immediate-release layer and a completely filled structure for the sustained-release layer) were applied. Secondarily, the potential of polyvinyl alcohol to function as a multifaceted polymeric matrix for both the immediate and slow-release layers was explored, with the objective of promoting the real-life applicability of the technique by downsizing the number of materials required to obtain versatile pharmaceutical products. The present study is a step forward in the translation of HME-FDM-3DP into a pharmaceutical manufacturing methodology.
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spelling pubmed-105374892023-09-29 Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System Crișan, Andrea Gabriela Porfire, Alina Iurian, Sonia Rus, Lucia Maria Lucăcel Ciceo, Raluca Turza, Alexandru Tomuță, Ioan Pharmaceuticals (Basel) Article Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the modulation of drug release profiles is crucial to ensure the superior efficacy and safety of modern 3D-printed medications compared to those of conventional ones. Our work aims to solidify the groundwork for the preparation of 3D-printed tablets that ensure the sustained release of diclofenac sodium. Specifically, we achieved the fast release of a diclofenac sodium dose to allow for the prompt onset of its pharmacological effect, further sustaining by the slow release of another dose to maintain the effect over a prolonged timeframe. In this regard, proper formulation and design strategies (a honeycomb structure for the immediate-release layer and a completely filled structure for the sustained-release layer) were applied. Secondarily, the potential of polyvinyl alcohol to function as a multifaceted polymeric matrix for both the immediate and slow-release layers was explored, with the objective of promoting the real-life applicability of the technique by downsizing the number of materials required to obtain versatile pharmaceutical products. The present study is a step forward in the translation of HME-FDM-3DP into a pharmaceutical manufacturing methodology. MDPI 2023-09-19 /pmc/articles/PMC10537489/ /pubmed/37765129 http://dx.doi.org/10.3390/ph16091321 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crișan, Andrea Gabriela
Porfire, Alina
Iurian, Sonia
Rus, Lucia Maria
Lucăcel Ciceo, Raluca
Turza, Alexandru
Tomuță, Ioan
Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System
title Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System
title_full Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System
title_fullStr Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System
title_full_unstemmed Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System
title_short Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System
title_sort development of a bilayer tablet by fused deposition modeling as a sustained-release drug delivery system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537489/
https://www.ncbi.nlm.nih.gov/pubmed/37765129
http://dx.doi.org/10.3390/ph16091321
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