Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression

BACKGROUND: NPM1 is a phosphoprotein highly abundant in the nucleolus. However, additional nuclear functions have been attributed to NPM1, probably through interaction with other nuclear factors. DOT1L is one interaction partner of NPM1 that catalyzes methylation of histone H3 at lysine 79 (H3K79)....

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Detalles Bibliográficos
Autores principales: Izzo, Annalisa, Akol, Ipek, Villarreal, Alejandro, Lebel, Shannon, Garcia-Miralles, Marta, Cheffer, Arquimedes, Bovio, Patrick, Heidrich, Stefanie, Vogel, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537513/
https://www.ncbi.nlm.nih.gov/pubmed/37759327
http://dx.doi.org/10.1186/s13072-023-00511-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537513/
https://www.ncbi.nlm.nih.gov/pubmed/37759327
http://dx.doi.org/10.1186/s13072-023-00511-9

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