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CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

Latent HIV-1 provirus represents the barrier toward a cure for infection and is dependent upon the host RNA Polymerase (Pol) II machinery for reemergence. Here, we find that inhibitors of the RNA Pol II mediator kinases CDK8/19, Senexin A and BRD6989, inhibit induction of HIV-1 expression in respons...

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Detalles Bibliográficos
Autores principales:	Horvath, Riley M., Brumme, Zabrina L., Sadowski, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537590/ https://www.ncbi.nlm.nih.gov/pubmed/37671866 http://dx.doi.org/10.1128/jvi.00923-23

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