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Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review
Background and Aims: The genetic risk score (GRS) is an important tool for estimating the total genetic contribution or susceptibility to a certain outcome of interest in an individual, taking into account their genetic risk alleles. This study aims to systematically review the association between t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537716/ https://www.ncbi.nlm.nih.gov/pubmed/37764823 http://dx.doi.org/10.3390/nu15184040 |
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author | Almaghrbi, Heba Al-Shafai, Mashael Al-Asmakh, Maha Bawadi, Hiba |
author_facet | Almaghrbi, Heba Al-Shafai, Mashael Al-Asmakh, Maha Bawadi, Hiba |
author_sort | Almaghrbi, Heba |
collection | PubMed |
description | Background and Aims: The genetic risk score (GRS) is an important tool for estimating the total genetic contribution or susceptibility to a certain outcome of interest in an individual, taking into account their genetic risk alleles. This study aims to systematically review the association between the GRS of low vitamin D with different noncommunicable diseases/markers. Methods: The article was first registered in PROSPERO CRD42023406929. PubMed and Embase were searched from the time of inception until March 2023 to capture all the literature related to the vitamin D genetic risk score (vD-GRS) in association with noncommunicable diseases. This was performed using comprehensive search terms including “Genetic Risk Score” OR “Genetics risk assessment” OR “Genome-wide risk score” AND “Vitamin D” OR 25(HO)D OR “25-hydroxyvitamin D”. Results: Eleven eligible studies were included in this study. Three studies reported a significant association between vD-GRS and metabolic parameters, including body fat percentage, body mass index, glycated hemoglobin, and fasting blood glucose. Moreover, colorectal cancer overall mortality and the risk of developing arterial fibrillation were also found to be associated with genetically deprived vitamin D levels. Conclusions: This systematic review highlights the genetic contribution of low-vitamin-D-risk single nucleotides polymorphisms (SNPs) as an accumulative factor associated with different non-communicable diseases/markers, including cancer mortality and the risk of developing obesity, type 2 diabetes, and cardiovascular diseases such as arterial fibrillation. |
format | Online Article Text |
id | pubmed-10537716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105377162023-09-29 Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review Almaghrbi, Heba Al-Shafai, Mashael Al-Asmakh, Maha Bawadi, Hiba Nutrients Systematic Review Background and Aims: The genetic risk score (GRS) is an important tool for estimating the total genetic contribution or susceptibility to a certain outcome of interest in an individual, taking into account their genetic risk alleles. This study aims to systematically review the association between the GRS of low vitamin D with different noncommunicable diseases/markers. Methods: The article was first registered in PROSPERO CRD42023406929. PubMed and Embase were searched from the time of inception until March 2023 to capture all the literature related to the vitamin D genetic risk score (vD-GRS) in association with noncommunicable diseases. This was performed using comprehensive search terms including “Genetic Risk Score” OR “Genetics risk assessment” OR “Genome-wide risk score” AND “Vitamin D” OR 25(HO)D OR “25-hydroxyvitamin D”. Results: Eleven eligible studies were included in this study. Three studies reported a significant association between vD-GRS and metabolic parameters, including body fat percentage, body mass index, glycated hemoglobin, and fasting blood glucose. Moreover, colorectal cancer overall mortality and the risk of developing arterial fibrillation were also found to be associated with genetically deprived vitamin D levels. Conclusions: This systematic review highlights the genetic contribution of low-vitamin-D-risk single nucleotides polymorphisms (SNPs) as an accumulative factor associated with different non-communicable diseases/markers, including cancer mortality and the risk of developing obesity, type 2 diabetes, and cardiovascular diseases such as arterial fibrillation. MDPI 2023-09-18 /pmc/articles/PMC10537716/ /pubmed/37764823 http://dx.doi.org/10.3390/nu15184040 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Almaghrbi, Heba Al-Shafai, Mashael Al-Asmakh, Maha Bawadi, Hiba Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review |
title | Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review |
title_full | Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review |
title_fullStr | Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review |
title_full_unstemmed | Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review |
title_short | Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review |
title_sort | association of vitamin d genetic risk score with noncommunicable diseases: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537716/ https://www.ncbi.nlm.nih.gov/pubmed/37764823 http://dx.doi.org/10.3390/nu15184040 |
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