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Development of a high-affinity anti-bovine PD-1 rabbit–bovine chimeric antibody using an efficient selection and large production system

Immune checkpoint molecules PD-1/PD-L1 cause T-cell exhaustion and contribute to disease progression in chronic infections of cattle. We established monoclonal antibodies (mAbs) that specifically inhibit the binding of bovine PD-1/PD-L1; however, conventional anti-PD-1 mAbs are not suitable as thera...

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Detalles Bibliográficos
Autores principales:	Okagawa, Tomohiro, Konnai, Satoru, Goto, Shinya, Sajiki, Yamato, Ganbaatar, Otgontuya, Watari, Kei, Nakamura, Hayato, Wang, Cai-Xia, Tachibana, Taro, Kato, Yukinari, Kameda, Yayoi, Kohara, Junko, Terasaki, Nobuhiro, Kubota, Manabu, Takeda, Akira, Takahashi, Hirofumi, Suzuki, Yasuhiko, Maekawa, Naoya, Murata, Shiro, Ohashi, Kazuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537840/ https://www.ncbi.nlm.nih.gov/pubmed/37759311 http://dx.doi.org/10.1186/s13567-023-01213-6

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