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Burden of HPV-Related Hospitalization in Germany from 2000 to 2021

HPV has been linked to the development of precancerous and cancerous lesions. The aim of this study was to evaluate the burden of HPV-related hospitalization in Germany from 2000 to 2021 and the potential impact of the COVID-19 pandemic on it. Methods: We performed a retrospective query using data f...

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Autores principales: Tampakoudis, Georgios, Anastasiou, Olympia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538031/
https://www.ncbi.nlm.nih.gov/pubmed/37766265
http://dx.doi.org/10.3390/v15091857
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author Tampakoudis, Georgios
Anastasiou, Olympia E.
author_facet Tampakoudis, Georgios
Anastasiou, Olympia E.
author_sort Tampakoudis, Georgios
collection PubMed
description HPV has been linked to the development of precancerous and cancerous lesions. The aim of this study was to evaluate the burden of HPV-related hospitalization in Germany from 2000 to 2021 and the potential impact of the COVID-19 pandemic on it. Methods: We performed a retrospective query using data from the German Statistical Office from 2000 to 2021, including hospital admission, inpatient mortality and hospital stay length data on cervical cancer/dysplasia, female genitourinary tract, anal, penile, head and neck cancers. Results: The HPV-attributable hospitalization rate per 100,000 inhabitants in Germany has decreased over time, from 89 cases in 2000 to 60 in 2021, with an average annual percent change (AAPC) of −1.93 (CI −2.08–−1.79, p < 0.05). The same trend was observed for the average hospital stay, which declined from 9 to 7 days, with an AAPC of −1.33 (CI −1.52–−1.21, p < 0.05). An undulating but overall slightly declining pattern was observed for the inpatient mortality (AAPC −0.92, CI −1.21–−0.64, p < 0.05). We observed a reduction in the hospitalization rates for invasive and non-invasive cervical cancer, which was observed in almost all age groups and in all German federal states. Conclusion: Our study provides a comprehensive analysis of the trends in HPV-related hospitalizations over the past two decades. The decline in hospitalization rates for cervical cancer and dysplasia suggests the potential efficacy of the HPV vaccination and screening programs.
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spelling pubmed-105380312023-09-29 Burden of HPV-Related Hospitalization in Germany from 2000 to 2021 Tampakoudis, Georgios Anastasiou, Olympia E. Viruses Communication HPV has been linked to the development of precancerous and cancerous lesions. The aim of this study was to evaluate the burden of HPV-related hospitalization in Germany from 2000 to 2021 and the potential impact of the COVID-19 pandemic on it. Methods: We performed a retrospective query using data from the German Statistical Office from 2000 to 2021, including hospital admission, inpatient mortality and hospital stay length data on cervical cancer/dysplasia, female genitourinary tract, anal, penile, head and neck cancers. Results: The HPV-attributable hospitalization rate per 100,000 inhabitants in Germany has decreased over time, from 89 cases in 2000 to 60 in 2021, with an average annual percent change (AAPC) of −1.93 (CI −2.08–−1.79, p < 0.05). The same trend was observed for the average hospital stay, which declined from 9 to 7 days, with an AAPC of −1.33 (CI −1.52–−1.21, p < 0.05). An undulating but overall slightly declining pattern was observed for the inpatient mortality (AAPC −0.92, CI −1.21–−0.64, p < 0.05). We observed a reduction in the hospitalization rates for invasive and non-invasive cervical cancer, which was observed in almost all age groups and in all German federal states. Conclusion: Our study provides a comprehensive analysis of the trends in HPV-related hospitalizations over the past two decades. The decline in hospitalization rates for cervical cancer and dysplasia suggests the potential efficacy of the HPV vaccination and screening programs. MDPI 2023-08-31 /pmc/articles/PMC10538031/ /pubmed/37766265 http://dx.doi.org/10.3390/v15091857 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Tampakoudis, Georgios
Anastasiou, Olympia E.
Burden of HPV-Related Hospitalization in Germany from 2000 to 2021
title Burden of HPV-Related Hospitalization in Germany from 2000 to 2021
title_full Burden of HPV-Related Hospitalization in Germany from 2000 to 2021
title_fullStr Burden of HPV-Related Hospitalization in Germany from 2000 to 2021
title_full_unstemmed Burden of HPV-Related Hospitalization in Germany from 2000 to 2021
title_short Burden of HPV-Related Hospitalization in Germany from 2000 to 2021
title_sort burden of hpv-related hospitalization in germany from 2000 to 2021
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538031/
https://www.ncbi.nlm.nih.gov/pubmed/37766265
http://dx.doi.org/10.3390/v15091857
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