Cargando…

Targeting SARS-CoV-2 Macrodomain-1 to Restore the Innate Immune Response Using In Silico Screening of Medicinal Compounds and Free Energy Calculation Approaches

Among the different drug targets of SARS-CoV-2, a multi-domain protein known as NSP3 is a critical element of the translational and replication machinery. The macrodomain-I, in particular, has been reported to have an essential role in the viral attack on the innate immune response. In this study, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohammad, Anwar, Alshawaf, Eman, Arefanian, Hossein, Marafie, Sulaiman K., Khan, Abbas, Wei, Dong-Qing, Al-Mulla, Fahd, Abubaker, Jehad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538035/ https://www.ncbi.nlm.nih.gov/pubmed/37766313 http://dx.doi.org/10.3390/v15091907

Ejemplares similares

Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity
por: Mohammad, Anwar, et al.
Publicado: (2021)

Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2
por: Mohammad, Anwar, et al.
Publicado: (2020)

Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10–nsp16 Complex of SARS-CoV-2
por: Mohammad, Anwar, et al.
Publicado: (2021)

Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approach
por: Alshawaf, Eman, et al.
Publicado: (2022)

Exploring the Binding Mechanism of NRG1–ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression
por: Marafie, Sulaiman K., et al.
Publicado: (2023)

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells
por: Marafie, Sulaiman K., et al.
Publicado: (2019)

Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy
por: Al Shawaf, Eman, et al.
Publicado: (2020)

An Overview of the Role of Furin in Type 2 Diabetes
por: Marafie, Sulaiman K., et al.
Publicado: (2023)

Structural modelling of SARS-CoV-2 alpha variant (B.1.1.7) suggests enhanced furin binding and infectivity
por: Mohammad, Anwar, et al.
Publicado: (2021)

Structural-Dynamics and Binding Analysis of RBD from SARS-CoV-2 Variants of Concern (VOCs) and GRP78 Receptor Revealed Basis for Higher Infectivity
por: Khan, Abbas, et al.
Publicado: (2021)

Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3
por: Abu-Farha, Mohamed, et al.
Publicado: (2019)

Remdesivir MD Simulations Suggest a More Favourable Binding to SARS-CoV-2 RNA Dependent RNA Polymerase Mutant P323L Than Wild-Type
por: Mohammad, Anwar, et al.
Publicado: (2021)

Association of COVID-19 Vaccines ChAdOx1-S and BNT162b2 with Circulating Levels of Coagulation Factors and Antithrombin
por: Hasan, Amal, et al.
Publicado: (2022)

Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases
por: Alterki, Abdulmohsen, et al.
Publicado: (2023)

Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment
por: Arefanian, Hossein, et al.
Publicado: (2021)

Relevance between COVID-19 and host genetics of immune response
por: Taher, Ibrahim, et al.
Publicado: (2021)

Association of significantly elevated plasma levels of NGAL and IGFBP4 in patients with diabetic nephropathy
por: Ali, Hamad, et al.
Publicado: (2022)

Early insight into antibody-dependent enhancement after SARS-CoV-2 mRNA vaccination
por: Hasan, Amal, et al.
Publicado: (2021)

Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity
por: Cherian, Preethi, et al.
Publicado: (2021)

Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain
por: Anmangandla, Ananya, et al.
Publicado: (2023)

The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation
por: Abu-Farha, Mohamed, et al.
Publicado: (2023)

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases
por: Leung, Anthony K. L., et al.
Publicado: (2018)

Editorial: Advances in the research of diabetic nephropathy, volume II
por: Iizuka, Katsumi, et al.
Publicado: (2023)

Editorial: Advances in the research of diabetic nephropathy
por: Abu-Farha, Mohamed, et al.
Publicado: (2023)

Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology
por: Bitar, Milad S., et al.
Publicado: (2018)

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis
por: Fehr, Anthony R., et al.
Publicado: (2018)

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
por: Alhammad, Yousef M. O., et al.
Publicado: (2020)

Functionally-focused algorithmic analysis of high resolution microarray-CGH genomic landscapes demonstrates comparable genomic copy number aberrations in MSI and MSS sporadic colorectal cancer
por: Ali, Hamad, et al.
Publicado: (2017)

FTO Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection
por: Fehr, Anthony R., et al.
Publicado: (2016)

Neutral sphingomyelinase‐2 and cardiometabolic diseases
por: Sindhu, Sardar, et al.
Publicado: (2021)

Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation
por: Kochumon, Shihab, et al.
Publicado: (2021)

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation
por: Lee, Hyunmi, et al.
Publicado: (2011)

Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain
por: Haikarainen, Teemu, et al.
Publicado: (2016)

The macrodomain family: Rethinking an ancient domain from evolutionary perspectives
por: Li, XiaoLei, et al.
Publicado: (2013)

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential
por: Rack, Johannes Gregor Matthias, et al.
Publicado: (2020)

Host ADP-ribosylation and the SARS-CoV-2 macrodomain
por: Hoch, Nicolas C.
Publicado: (2021)

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses
por: Leung, Anthony K. L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_57bbqjs8fomuiu82sijs3hi9u5