Cargando…
A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand
Hepatitis A virus (HAV) and hepatitis E virus (HEV) infections often present as acute hepatitis with prodromal symptoms. These infections, transmitted via the oral–enteral route, constitute significant public health challenges, particularly in developing countries with subpar sanitary systems. The a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538055/ https://www.ncbi.nlm.nih.gov/pubmed/37766294 http://dx.doi.org/10.3390/v15091888 |
_version_ | 1785113239089053696 |
---|---|
author | Khongviwatsathien, Sirajuk Thaweerat, Wajana Atthakitmongkol, Thanapat Chotiyaputta, Watcharasak Tanwandee, Tawesak |
author_facet | Khongviwatsathien, Sirajuk Thaweerat, Wajana Atthakitmongkol, Thanapat Chotiyaputta, Watcharasak Tanwandee, Tawesak |
author_sort | Khongviwatsathien, Sirajuk |
collection | PubMed |
description | Hepatitis A virus (HAV) and hepatitis E virus (HEV) infections often present as acute hepatitis with prodromal symptoms. These infections, transmitted via the oral–enteral route, constitute significant public health challenges, particularly in developing countries with subpar sanitary systems. The aim of the study was to describe the clinical manifestations, laboratory findings, and outcomes of hepatitis A and hepatitis E infections in Thailand. We conducted a retrospective chart review and analysis of 152 patients diagnosed with acute hepatitis A or hepatitis E from January 2007 to August 2018 at Siriraj Hospital. The hepatitis E cohort was older with a greater prevalence of comorbidities (hypertension, diabetes mellitus, chronic kidney disease, chronic hepatitis B, and post-kidney transplantation status) than the hepatitis A cohort. While the majority of hepatitis A patients presented with fever (98%) and jaundice (96%), these symptoms were less pronounced in hepatitis E patients. Furthermore, hepatitis A patients exhibited significantly higher aminotransferase and total bilirubin levels. However, clinical outcomes, such as hospitalization rates, progression to acute liver failure, and mortality, were comparable across both groups. In conclusion, although the clinical manifestations of hepatitis A and hepatitis E were similar, fever and jaundice were more prevalent and aminotransferase and bilirubin levels were higher in the HAV-infected group. |
format | Online Article Text |
id | pubmed-10538055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105380552023-09-29 A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand Khongviwatsathien, Sirajuk Thaweerat, Wajana Atthakitmongkol, Thanapat Chotiyaputta, Watcharasak Tanwandee, Tawesak Viruses Article Hepatitis A virus (HAV) and hepatitis E virus (HEV) infections often present as acute hepatitis with prodromal symptoms. These infections, transmitted via the oral–enteral route, constitute significant public health challenges, particularly in developing countries with subpar sanitary systems. The aim of the study was to describe the clinical manifestations, laboratory findings, and outcomes of hepatitis A and hepatitis E infections in Thailand. We conducted a retrospective chart review and analysis of 152 patients diagnosed with acute hepatitis A or hepatitis E from January 2007 to August 2018 at Siriraj Hospital. The hepatitis E cohort was older with a greater prevalence of comorbidities (hypertension, diabetes mellitus, chronic kidney disease, chronic hepatitis B, and post-kidney transplantation status) than the hepatitis A cohort. While the majority of hepatitis A patients presented with fever (98%) and jaundice (96%), these symptoms were less pronounced in hepatitis E patients. Furthermore, hepatitis A patients exhibited significantly higher aminotransferase and total bilirubin levels. However, clinical outcomes, such as hospitalization rates, progression to acute liver failure, and mortality, were comparable across both groups. In conclusion, although the clinical manifestations of hepatitis A and hepatitis E were similar, fever and jaundice were more prevalent and aminotransferase and bilirubin levels were higher in the HAV-infected group. MDPI 2023-09-07 /pmc/articles/PMC10538055/ /pubmed/37766294 http://dx.doi.org/10.3390/v15091888 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khongviwatsathien, Sirajuk Thaweerat, Wajana Atthakitmongkol, Thanapat Chotiyaputta, Watcharasak Tanwandee, Tawesak A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand |
title | A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand |
title_full | A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand |
title_fullStr | A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand |
title_full_unstemmed | A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand |
title_short | A Comparison of Clinical Manifestations and Outcomes between Acute Sporadic Hepatitis A and Hepatitis E Infections in Thailand |
title_sort | comparison of clinical manifestations and outcomes between acute sporadic hepatitis a and hepatitis e infections in thailand |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538055/ https://www.ncbi.nlm.nih.gov/pubmed/37766294 http://dx.doi.org/10.3390/v15091888 |
work_keys_str_mv | AT khongviwatsathiensirajuk acomparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT thaweeratwajana acomparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT atthakitmongkolthanapat acomparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT chotiyaputtawatcharasak acomparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT tanwandeetawesak acomparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT khongviwatsathiensirajuk comparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT thaweeratwajana comparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT atthakitmongkolthanapat comparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT chotiyaputtawatcharasak comparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand AT tanwandeetawesak comparisonofclinicalmanifestationsandoutcomesbetweenacutesporadichepatitisaandhepatitiseinfectionsinthailand |