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Protective versus Pathogenic Type I Interferon Responses during Virus Infections

Following virus infections, type I interferons are synthesized to induce the expression of antiviral molecules and interfere with virus replication. The importance of early antiviral type I IFN response against virus invasion has been emphasized during COVID-19 as well as in studies on the microbiom...

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Autores principales: Jung, Kwang Il, McKenna, Savannah, Vijayamahantesh, Vijayamahantesh, He, Ying, Hahm, Bumsuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538102/
https://www.ncbi.nlm.nih.gov/pubmed/37766322
http://dx.doi.org/10.3390/v15091916
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author Jung, Kwang Il
McKenna, Savannah
Vijayamahantesh, Vijayamahantesh
He, Ying
Hahm, Bumsuk
author_facet Jung, Kwang Il
McKenna, Savannah
Vijayamahantesh, Vijayamahantesh
He, Ying
Hahm, Bumsuk
author_sort Jung, Kwang Il
collection PubMed
description Following virus infections, type I interferons are synthesized to induce the expression of antiviral molecules and interfere with virus replication. The importance of early antiviral type I IFN response against virus invasion has been emphasized during COVID-19 as well as in studies on the microbiome. Further, type I IFNs can directly act on various immune cells to enhance protective host immune responses to viral infections. However, accumulating data indicate that IFN responses can be harmful to the host by instigating inflammatory responses or inducing T cell suppression during virus infections. Also, inhibition of lymphocyte and dendritic cell development can be caused by type I IFN, which is independent of the traditional signal transducer and activator of transcription 1 signaling. Additionally, IFNs were shown to impair airway epithelial cell proliferation, which may affect late-stage lung tissue recovery from the infection. As such, type I IFN–virus interaction research is diverse, including host antiviral innate immune mechanisms in cells, viral strategies of IFN evasion, protective immunity, excessive inflammation, immune suppression, and regulation of tissue repair. In this report, these IFN activities are summarized with an emphasis placed on the functions of type I IFNs recently observed during acute or chronic virus infections.
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spelling pubmed-105381022023-09-29 Protective versus Pathogenic Type I Interferon Responses during Virus Infections Jung, Kwang Il McKenna, Savannah Vijayamahantesh, Vijayamahantesh He, Ying Hahm, Bumsuk Viruses Review Following virus infections, type I interferons are synthesized to induce the expression of antiviral molecules and interfere with virus replication. The importance of early antiviral type I IFN response against virus invasion has been emphasized during COVID-19 as well as in studies on the microbiome. Further, type I IFNs can directly act on various immune cells to enhance protective host immune responses to viral infections. However, accumulating data indicate that IFN responses can be harmful to the host by instigating inflammatory responses or inducing T cell suppression during virus infections. Also, inhibition of lymphocyte and dendritic cell development can be caused by type I IFN, which is independent of the traditional signal transducer and activator of transcription 1 signaling. Additionally, IFNs were shown to impair airway epithelial cell proliferation, which may affect late-stage lung tissue recovery from the infection. As such, type I IFN–virus interaction research is diverse, including host antiviral innate immune mechanisms in cells, viral strategies of IFN evasion, protective immunity, excessive inflammation, immune suppression, and regulation of tissue repair. In this report, these IFN activities are summarized with an emphasis placed on the functions of type I IFNs recently observed during acute or chronic virus infections. MDPI 2023-09-13 /pmc/articles/PMC10538102/ /pubmed/37766322 http://dx.doi.org/10.3390/v15091916 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jung, Kwang Il
McKenna, Savannah
Vijayamahantesh, Vijayamahantesh
He, Ying
Hahm, Bumsuk
Protective versus Pathogenic Type I Interferon Responses during Virus Infections
title Protective versus Pathogenic Type I Interferon Responses during Virus Infections
title_full Protective versus Pathogenic Type I Interferon Responses during Virus Infections
title_fullStr Protective versus Pathogenic Type I Interferon Responses during Virus Infections
title_full_unstemmed Protective versus Pathogenic Type I Interferon Responses during Virus Infections
title_short Protective versus Pathogenic Type I Interferon Responses during Virus Infections
title_sort protective versus pathogenic type i interferon responses during virus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538102/
https://www.ncbi.nlm.nih.gov/pubmed/37766322
http://dx.doi.org/10.3390/v15091916
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