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Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs

SIMPLE SUMMARY: Of intracranial tumors, primary central nervous system lymphoma (PCNSL) rarely occurs in dogs. Here, we describe two dogs with neurological symptoms and intracranial disseminated lesions that appeared on magnetic resonance imaging (MRI). PCNSL or secondary central nervous system lymp...

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Autores principales: Mizutani, Yuko, Inoue, Yoshiyuki, Goda, Yoshimichi, Mizutani, Shinya, Asanuma, Taketoshi, Miura, Naoki, Hidaka, Yuichi, Sato, Reiichiro, Satoh, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538104/
https://www.ncbi.nlm.nih.gov/pubmed/37756055
http://dx.doi.org/10.3390/vetsci10090533
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author Mizutani, Yuko
Inoue, Yoshiyuki
Goda, Yoshimichi
Mizutani, Shinya
Asanuma, Taketoshi
Miura, Naoki
Hidaka, Yuichi
Sato, Reiichiro
Satoh, Hiroyuki
author_facet Mizutani, Yuko
Inoue, Yoshiyuki
Goda, Yoshimichi
Mizutani, Shinya
Asanuma, Taketoshi
Miura, Naoki
Hidaka, Yuichi
Sato, Reiichiro
Satoh, Hiroyuki
author_sort Mizutani, Yuko
collection PubMed
description SIMPLE SUMMARY: Of intracranial tumors, primary central nervous system lymphoma (PCNSL) rarely occurs in dogs. Here, we describe two dogs with neurological symptoms and intracranial disseminated lesions that appeared on magnetic resonance imaging (MRI). PCNSL or secondary central nervous system lymphoma was diagnosed on the basis of MRI findings and cerebrospinal fluid examinations. Nimustine (ACNU) is a nitrosourea alkylating agent, a class of drugs that includes lomustine. The dogs in this study were treated with combined chemotherapy comprising nimustine and prednisolone, which achieved complete or nearly complete remission of neurological symptoms and long-term survival (>2583 days and 1218 days), but with some problematic adverse effects. ABSTRACT: Of intracranial tumors, primary central nervous system lymphoma (PCNSL) is rare in dogs. Herein, we describe our experience with two dogs (a 3-year-old intact female toy poodle and a 5-year-old spayed female toy poodle) that developed neurological symptoms. Magnetic resonance imaging (MRI) revealed intracranial disseminated lesions. Cerebrospinal fluid (CSF) examination revealed pleocytosis and B-cell monoclonal proliferation in both cases. PCNSL or secondary central nervous system lymphoma (SCNSL) was diagnosed on the basis of MRI findings and CSF examinations. Nimustine (ACNU) is a nitrosourea alkylating agent, a class of drugs that includes lomustine. Nimustine is mainly used to treat human intracranial neoplasia because of its high permeability across the blood-brain barrier. The dogs in this study were treated with combined chemotherapy comprising nimustine and prednisolone, which achieved complete or nearly complete remission of neurological symptoms and long-term survival (>2583 days and 1218 days), but with problematic adverse effects. We determined that the dose of nimustine for canine PCNSL or SCNSL with intravenous infusion was 25–30 mg/m(2) every 3–4 weeks for a total of four times; however, the data were insufficient to determine the optimal regimen.
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spelling pubmed-105381042023-09-29 Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs Mizutani, Yuko Inoue, Yoshiyuki Goda, Yoshimichi Mizutani, Shinya Asanuma, Taketoshi Miura, Naoki Hidaka, Yuichi Sato, Reiichiro Satoh, Hiroyuki Vet Sci Case Report SIMPLE SUMMARY: Of intracranial tumors, primary central nervous system lymphoma (PCNSL) rarely occurs in dogs. Here, we describe two dogs with neurological symptoms and intracranial disseminated lesions that appeared on magnetic resonance imaging (MRI). PCNSL or secondary central nervous system lymphoma was diagnosed on the basis of MRI findings and cerebrospinal fluid examinations. Nimustine (ACNU) is a nitrosourea alkylating agent, a class of drugs that includes lomustine. The dogs in this study were treated with combined chemotherapy comprising nimustine and prednisolone, which achieved complete or nearly complete remission of neurological symptoms and long-term survival (>2583 days and 1218 days), but with some problematic adverse effects. ABSTRACT: Of intracranial tumors, primary central nervous system lymphoma (PCNSL) is rare in dogs. Herein, we describe our experience with two dogs (a 3-year-old intact female toy poodle and a 5-year-old spayed female toy poodle) that developed neurological symptoms. Magnetic resonance imaging (MRI) revealed intracranial disseminated lesions. Cerebrospinal fluid (CSF) examination revealed pleocytosis and B-cell monoclonal proliferation in both cases. PCNSL or secondary central nervous system lymphoma (SCNSL) was diagnosed on the basis of MRI findings and CSF examinations. Nimustine (ACNU) is a nitrosourea alkylating agent, a class of drugs that includes lomustine. Nimustine is mainly used to treat human intracranial neoplasia because of its high permeability across the blood-brain barrier. The dogs in this study were treated with combined chemotherapy comprising nimustine and prednisolone, which achieved complete or nearly complete remission of neurological symptoms and long-term survival (>2583 days and 1218 days), but with problematic adverse effects. We determined that the dose of nimustine for canine PCNSL or SCNSL with intravenous infusion was 25–30 mg/m(2) every 3–4 weeks for a total of four times; however, the data were insufficient to determine the optimal regimen. MDPI 2023-08-22 /pmc/articles/PMC10538104/ /pubmed/37756055 http://dx.doi.org/10.3390/vetsci10090533 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mizutani, Yuko
Inoue, Yoshiyuki
Goda, Yoshimichi
Mizutani, Shinya
Asanuma, Taketoshi
Miura, Naoki
Hidaka, Yuichi
Sato, Reiichiro
Satoh, Hiroyuki
Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs
title Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs
title_full Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs
title_fullStr Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs
title_full_unstemmed Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs
title_short Successful Treatment of Central Nervous System Lymphoma with Combination Therapy of Nimustine and Prednisolone in Two Dogs
title_sort successful treatment of central nervous system lymphoma with combination therapy of nimustine and prednisolone in two dogs
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538104/
https://www.ncbi.nlm.nih.gov/pubmed/37756055
http://dx.doi.org/10.3390/vetsci10090533
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