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Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome
SIMPLE SUMMARY: Myocardial dysfunction associated with systemic inflammatory response syndrome (SIRS) in people is identified to be related to considerably increased mortality. It has been recently also hypothesized that myocardial lesions may be present in cats with SIRS. The purpose of this study...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538112/ https://www.ncbi.nlm.nih.gov/pubmed/37756092 http://dx.doi.org/10.3390/vetsci10090570 |
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author | Pugliese, Michela Napoli, Ettore La Maestra, Rocky Or, Mehmet Erman Bilgiç, Bengü Previti, Annalisa Biondi, Vito Passantino, Annamaria |
author_facet | Pugliese, Michela Napoli, Ettore La Maestra, Rocky Or, Mehmet Erman Bilgiç, Bengü Previti, Annalisa Biondi, Vito Passantino, Annamaria |
author_sort | Pugliese, Michela |
collection | PubMed |
description | SIMPLE SUMMARY: Myocardial dysfunction associated with systemic inflammatory response syndrome (SIRS) in people is identified to be related to considerably increased mortality. It has been recently also hypothesized that myocardial lesions may be present in cats with SIRS. The purpose of this study was to identify a possible myocardial dysfunction in cats with SIRS, evaluating cardiac troponin and electrocardiographic findings. Results obtained in this study demonstrate that cats with SIRS have increased cardiac troponin levels and alterations at electrocardiographic examination, consistent with the presence of myocardial dysfunction. ABSTRACT: Several studies conducted on humans demonstrate the increase in cardiac troponins and the onset of arrhythmias in the course of systemic inflammatory response syndrome (SIRS). The aim of the current study was to assess the blood concentration of cardiac troponin I (cTnI) and electrocardiographic findings in SIRS-affected cats. Seventeen shorthair cats hospitalized with SIRS were enrolled (Group 1). SIRS diagnosis was performed based on the detection of at least two of the four criteria such as abnormal body temperature, abnormal heart rate (i.e., tachycardia or bradycardia), abnormal respiratory rate (i.e., tachypnea or bradypnea), and alterations of white blood cell number (i.e., leukocytes or band neutrophils). Ten cats screened for elective surgery such as neutering or dental procedures were evaluated as a control population (Group 2). They were considered healthy based on history, physical examination, hematological and biochemical profile, urinalysis, coprological exam, thyroxine assay, blood pressure measurement, and echocardiography. A physical examination, complete blood cell count, biochemistry test (including an electrolyte panel), electrocardiographic examination, and cTnI assay were carried out in each cat enrolled. Traumatic events, gastrointestinal, neoplastic, respiratory, and neurological disorders were identified as causes of SIRS in Group 1. In Group 1, a significantly higher concentration of cTnI than that in Group 2 was recorded (p = 0.004). In 37.5% of cats with SIRS, ventricular premature complexes occurring in couplets with multiform configuration were detected. Similarly, to humans, data herein reported would indicate possible cardiac damage present in cats with SIRS diagnosis. |
format | Online Article Text |
id | pubmed-10538112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105381122023-09-29 Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome Pugliese, Michela Napoli, Ettore La Maestra, Rocky Or, Mehmet Erman Bilgiç, Bengü Previti, Annalisa Biondi, Vito Passantino, Annamaria Vet Sci Article SIMPLE SUMMARY: Myocardial dysfunction associated with systemic inflammatory response syndrome (SIRS) in people is identified to be related to considerably increased mortality. It has been recently also hypothesized that myocardial lesions may be present in cats with SIRS. The purpose of this study was to identify a possible myocardial dysfunction in cats with SIRS, evaluating cardiac troponin and electrocardiographic findings. Results obtained in this study demonstrate that cats with SIRS have increased cardiac troponin levels and alterations at electrocardiographic examination, consistent with the presence of myocardial dysfunction. ABSTRACT: Several studies conducted on humans demonstrate the increase in cardiac troponins and the onset of arrhythmias in the course of systemic inflammatory response syndrome (SIRS). The aim of the current study was to assess the blood concentration of cardiac troponin I (cTnI) and electrocardiographic findings in SIRS-affected cats. Seventeen shorthair cats hospitalized with SIRS were enrolled (Group 1). SIRS diagnosis was performed based on the detection of at least two of the four criteria such as abnormal body temperature, abnormal heart rate (i.e., tachycardia or bradycardia), abnormal respiratory rate (i.e., tachypnea or bradypnea), and alterations of white blood cell number (i.e., leukocytes or band neutrophils). Ten cats screened for elective surgery such as neutering or dental procedures were evaluated as a control population (Group 2). They were considered healthy based on history, physical examination, hematological and biochemical profile, urinalysis, coprological exam, thyroxine assay, blood pressure measurement, and echocardiography. A physical examination, complete blood cell count, biochemistry test (including an electrolyte panel), electrocardiographic examination, and cTnI assay were carried out in each cat enrolled. Traumatic events, gastrointestinal, neoplastic, respiratory, and neurological disorders were identified as causes of SIRS in Group 1. In Group 1, a significantly higher concentration of cTnI than that in Group 2 was recorded (p = 0.004). In 37.5% of cats with SIRS, ventricular premature complexes occurring in couplets with multiform configuration were detected. Similarly, to humans, data herein reported would indicate possible cardiac damage present in cats with SIRS diagnosis. MDPI 2023-09-13 /pmc/articles/PMC10538112/ /pubmed/37756092 http://dx.doi.org/10.3390/vetsci10090570 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pugliese, Michela Napoli, Ettore La Maestra, Rocky Or, Mehmet Erman Bilgiç, Bengü Previti, Annalisa Biondi, Vito Passantino, Annamaria Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome |
title | Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome |
title_full | Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome |
title_fullStr | Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome |
title_full_unstemmed | Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome |
title_short | Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome |
title_sort | cardiac troponin i and electrocardiographic evaluation in hospitalized cats with systemic inflammatory response syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538112/ https://www.ncbi.nlm.nih.gov/pubmed/37756092 http://dx.doi.org/10.3390/vetsci10090570 |
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