Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report

Eperisone hydrochloride is a central muscle relaxant used to treat osteoporosis. Seizures are rare side effects of eperisone hydrochloride and have been previously reported in the medical literature in overdose situations but not at regular doses. This case report describes a 42-year-old male painte...

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Autores principales: Luo, Long, Yin, Jun, Li, Zhigang, Zhang, Wei, Yuan, Ying, Tang, Ying, Deng, Ye, Zhu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538527/
https://www.ncbi.nlm.nih.gov/pubmed/37780713
http://dx.doi.org/10.3389/fneur.2023.1240526
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author Luo, Long
Yin, Jun
Li, Zhigang
Zhang, Wei
Yuan, Ying
Tang, Ying
Deng, Ye
Zhu, Ling
author_facet Luo, Long
Yin, Jun
Li, Zhigang
Zhang, Wei
Yuan, Ying
Tang, Ying
Deng, Ye
Zhu, Ling
author_sort Luo, Long
collection PubMed
description Eperisone hydrochloride is a central muscle relaxant used to treat osteoporosis. Seizures are rare side effects of eperisone hydrochloride and have been previously reported in the medical literature in overdose situations but not at regular doses. This case report describes a 42-year-old male painter who developed severe bilateral tonic seizures after the initiation of eperisone hydrochloride at regular doses for low back pain. Symptoms gradually eased in the days following the discontinuation of eperisone hydrochloride and antiepileptic treatment, with no recurrence. This rare adverse drug reaction warrants clinical awareness; however, the mechanisms underlying these adverse reactions remain to be clarified.
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spelling pubmed-105385272023-09-29 Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report Luo, Long Yin, Jun Li, Zhigang Zhang, Wei Yuan, Ying Tang, Ying Deng, Ye Zhu, Ling Front Neurol Neurology Eperisone hydrochloride is a central muscle relaxant used to treat osteoporosis. Seizures are rare side effects of eperisone hydrochloride and have been previously reported in the medical literature in overdose situations but not at regular doses. This case report describes a 42-year-old male painter who developed severe bilateral tonic seizures after the initiation of eperisone hydrochloride at regular doses for low back pain. Symptoms gradually eased in the days following the discontinuation of eperisone hydrochloride and antiepileptic treatment, with no recurrence. This rare adverse drug reaction warrants clinical awareness; however, the mechanisms underlying these adverse reactions remain to be clarified. Frontiers Media S.A. 2023-09-14 /pmc/articles/PMC10538527/ /pubmed/37780713 http://dx.doi.org/10.3389/fneur.2023.1240526 Text en Copyright © 2023 Luo, Yin, Li, Zhang, Yuan, Tang, Deng and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Luo, Long
Yin, Jun
Li, Zhigang
Zhang, Wei
Yuan, Ying
Tang, Ying
Deng, Ye
Zhu, Ling
Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
title Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
title_full Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
title_fullStr Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
title_full_unstemmed Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
title_short Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
title_sort bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538527/
https://www.ncbi.nlm.nih.gov/pubmed/37780713
http://dx.doi.org/10.3389/fneur.2023.1240526
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