Engineered CD4 T cells expressing a membrane anchored viral inhibitor restrict HIV-1 through cis and trans mechanisms

HIV-1 infection of target cells can occur through either cell-free virions or cell-cell transmission in a virological synapse, with the latter mechanism of infection reported to be 100- to 1,000-fold more efficient. Neutralizing antibodies and entry inhibitors effectively block cell-free HIV-1, but...

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Detalles Bibliográficos
Autores principales: Wang, Weiming, Truong, Khanghy, Ye, Chaobaihui, Sharma, Suman, He, Huan, Liu, Lihong, Wen, Michael, Misra, Anisha, Zhou, Paul, Kimata, Jason T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538569/
https://www.ncbi.nlm.nih.gov/pubmed/37781368
http://dx.doi.org/10.3389/fimmu.2023.1167965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538569/
https://www.ncbi.nlm.nih.gov/pubmed/37781368
http://dx.doi.org/10.3389/fimmu.2023.1167965

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