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Engineered CD4 T cells expressing a membrane anchored viral inhibitor restrict HIV-1 through cis and trans mechanisms
HIV-1 infection of target cells can occur through either cell-free virions or cell-cell transmission in a virological synapse, with the latter mechanism of infection reported to be 100- to 1,000-fold more efficient. Neutralizing antibodies and entry inhibitors effectively block cell-free HIV-1, but...
Autores principales: | Wang, Weiming, Truong, Khanghy, Ye, Chaobaihui, Sharma, Suman, He, Huan, Liu, Lihong, Wen, Michael, Misra, Anisha, Zhou, Paul, Kimata, Jason T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538569/ https://www.ncbi.nlm.nih.gov/pubmed/37781368 http://dx.doi.org/10.3389/fimmu.2023.1167965 |
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