Research progress on the role of the Wnt signaling pathway in pituitary adenoma

Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear. The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Self-renewal of stem cells, and cell differentiation. It is rel...

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Autores principales: Wang, Wencai, Ma, Luyao, Zhao, Yongqiang, Liu, Menghao, Ye, Wei, Li, Xianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538627/
https://www.ncbi.nlm.nih.gov/pubmed/37780610
http://dx.doi.org/10.3389/fendo.2023.1216817
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author Wang, Wencai
Ma, Luyao
Zhao, Yongqiang
Liu, Menghao
Ye, Wei
Li, Xianfeng
author_facet Wang, Wencai
Ma, Luyao
Zhao, Yongqiang
Liu, Menghao
Ye, Wei
Li, Xianfeng
author_sort Wang, Wencai
collection PubMed
description Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear. The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Self-renewal of stem cells, and cell differentiation. It is related to the occurrence of various tumors, including PA. This article reviews the latest developments in Wnt pathway inhibitors and pathway-targeted drugs. It discusses the possibility of combining Wnt pathway inhibitors with immunotherapy to provide a theoretical basis for the combined treatment of PA.
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spelling pubmed-105386272023-09-29 Research progress on the role of the Wnt signaling pathway in pituitary adenoma Wang, Wencai Ma, Luyao Zhao, Yongqiang Liu, Menghao Ye, Wei Li, Xianfeng Front Endocrinol (Lausanne) Endocrinology Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear. The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Self-renewal of stem cells, and cell differentiation. It is related to the occurrence of various tumors, including PA. This article reviews the latest developments in Wnt pathway inhibitors and pathway-targeted drugs. It discusses the possibility of combining Wnt pathway inhibitors with immunotherapy to provide a theoretical basis for the combined treatment of PA. Frontiers Media S.A. 2023-09-14 /pmc/articles/PMC10538627/ /pubmed/37780610 http://dx.doi.org/10.3389/fendo.2023.1216817 Text en Copyright © 2023 Wang, Ma, Zhao, Liu, Ye and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wang, Wencai
Ma, Luyao
Zhao, Yongqiang
Liu, Menghao
Ye, Wei
Li, Xianfeng
Research progress on the role of the Wnt signaling pathway in pituitary adenoma
title Research progress on the role of the Wnt signaling pathway in pituitary adenoma
title_full Research progress on the role of the Wnt signaling pathway in pituitary adenoma
title_fullStr Research progress on the role of the Wnt signaling pathway in pituitary adenoma
title_full_unstemmed Research progress on the role of the Wnt signaling pathway in pituitary adenoma
title_short Research progress on the role of the Wnt signaling pathway in pituitary adenoma
title_sort research progress on the role of the wnt signaling pathway in pituitary adenoma
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538627/
https://www.ncbi.nlm.nih.gov/pubmed/37780610
http://dx.doi.org/10.3389/fendo.2023.1216817
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