Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans

mTORC1 (mechanistic target of rapamycin complex 1) is a metabolic sensor that promotes growth when nutrients are abundant. Ubiquitous inhibition of mTORC1 extends lifespan in multiple organisms but also disrupts several anabolic processes resulting in stunted growth, slowed development, reduced fert...

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Detalles Bibliográficos
Autores principales: Smith, Hannah J., Lanjuin, Anne, Sharma, Arpit, Prabhakar, Aditi, Nowak, Ewelina, Stine, Peter G., Sehgal, Rohan, Stojanovski, Klement, Towbin, Benjamin D., Mair, William B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538657/
https://www.ncbi.nlm.nih.gov/pubmed/37721956
http://dx.doi.org/10.1371/journal.pgen.1010938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538657/
https://www.ncbi.nlm.nih.gov/pubmed/37721956
http://dx.doi.org/10.1371/journal.pgen.1010938

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