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Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans
mTORC1 (mechanistic target of rapamycin complex 1) is a metabolic sensor that promotes growth when nutrients are abundant. Ubiquitous inhibition of mTORC1 extends lifespan in multiple organisms but also disrupts several anabolic processes resulting in stunted growth, slowed development, reduced fert...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538657/ https://www.ncbi.nlm.nih.gov/pubmed/37721956 http://dx.doi.org/10.1371/journal.pgen.1010938 |