Cargando…

Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022

Severe fever with thrombocytopenia syndrome virus (SFTSV), an etiological agent causing febrile human disease was identified as an emerging tick-borne bunyavirus. The clinical disease characteristics and case fatality rates of SFTSV may vary across distinct regions and among different variant genoty...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Yu-ting, Tian, Hong-pan, Xu, Jia-le, Liu, Man-qing, Cai, Kun, Chen, Shu-liang, Ni, Xue-bing, Li, Yi-rong, Hou, Wei, Chen, Liang-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538666/
https://www.ncbi.nlm.nih.gov/pubmed/37721962
http://dx.doi.org/10.1371/journal.pntd.0011654
_version_ 1785113352512471040
author Ren, Yu-ting
Tian, Hong-pan
Xu, Jia-le
Liu, Man-qing
Cai, Kun
Chen, Shu-liang
Ni, Xue-bing
Li, Yi-rong
Hou, Wei
Chen, Liang-jun
author_facet Ren, Yu-ting
Tian, Hong-pan
Xu, Jia-le
Liu, Man-qing
Cai, Kun
Chen, Shu-liang
Ni, Xue-bing
Li, Yi-rong
Hou, Wei
Chen, Liang-jun
author_sort Ren, Yu-ting
collection PubMed
description Severe fever with thrombocytopenia syndrome virus (SFTSV), an etiological agent causing febrile human disease was identified as an emerging tick-borne bunyavirus. The clinical disease characteristics and case fatality rates of SFTSV may vary across distinct regions and among different variant genotypes. From 2018 to 2022, we surveyed and recruited 202 severe fever with thrombocytopenia syndrome (SFTS) patients in Hubei Province, a high-incidence area of the epidemic, and conducted timely and systematic research on the disease characteristics, SFTSV diversity, and the correlation between virus genome variation and clinical diseases. Our study identified at least 6 genotypes of SFTSV prevalent in Hubei Province based on the analysis of the S, M, and L genome sequences of 88 virus strains. Strikingly, the dominant genotype of SFTSV was found to change during the years, indicating a dynamic shift in viral genetic diversity in the region. Phylogenetic analysis revealed the genetic exchange of Hubei SFTSV strains was relatively frequent, including 3 reassortment strains and 8 recombination strains. Despite the limited sample size, SFTSV C1 genotype may be associated with higher mortality compared to the other four genotypes, and the serum amyloid A (SAA) level, an inflammatory biomarker, was significantly elevated in these patients. Overall, our data summarize the disease characteristics of SFTSV in Hubei Province, highlight the profound changes in viral genetic diversity, and indicate the need for in-depth monitoring and exploration of the relationship between viral mutations and disease severity.
format Online
Article
Text
id pubmed-10538666
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-105386662023-09-29 Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022 Ren, Yu-ting Tian, Hong-pan Xu, Jia-le Liu, Man-qing Cai, Kun Chen, Shu-liang Ni, Xue-bing Li, Yi-rong Hou, Wei Chen, Liang-jun PLoS Negl Trop Dis Research Article Severe fever with thrombocytopenia syndrome virus (SFTSV), an etiological agent causing febrile human disease was identified as an emerging tick-borne bunyavirus. The clinical disease characteristics and case fatality rates of SFTSV may vary across distinct regions and among different variant genotypes. From 2018 to 2022, we surveyed and recruited 202 severe fever with thrombocytopenia syndrome (SFTS) patients in Hubei Province, a high-incidence area of the epidemic, and conducted timely and systematic research on the disease characteristics, SFTSV diversity, and the correlation between virus genome variation and clinical diseases. Our study identified at least 6 genotypes of SFTSV prevalent in Hubei Province based on the analysis of the S, M, and L genome sequences of 88 virus strains. Strikingly, the dominant genotype of SFTSV was found to change during the years, indicating a dynamic shift in viral genetic diversity in the region. Phylogenetic analysis revealed the genetic exchange of Hubei SFTSV strains was relatively frequent, including 3 reassortment strains and 8 recombination strains. Despite the limited sample size, SFTSV C1 genotype may be associated with higher mortality compared to the other four genotypes, and the serum amyloid A (SAA) level, an inflammatory biomarker, was significantly elevated in these patients. Overall, our data summarize the disease characteristics of SFTSV in Hubei Province, highlight the profound changes in viral genetic diversity, and indicate the need for in-depth monitoring and exploration of the relationship between viral mutations and disease severity. Public Library of Science 2023-09-18 /pmc/articles/PMC10538666/ /pubmed/37721962 http://dx.doi.org/10.1371/journal.pntd.0011654 Text en © 2023 Ren et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ren, Yu-ting
Tian, Hong-pan
Xu, Jia-le
Liu, Man-qing
Cai, Kun
Chen, Shu-liang
Ni, Xue-bing
Li, Yi-rong
Hou, Wei
Chen, Liang-jun
Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022
title Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022
title_full Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022
title_fullStr Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022
title_full_unstemmed Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022
title_short Extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in Hubei Province, China, 2018–2022
title_sort extensive genetic diversity of severe fever with thrombocytopenia syndrome virus circulating in hubei province, china, 2018–2022
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538666/
https://www.ncbi.nlm.nih.gov/pubmed/37721962
http://dx.doi.org/10.1371/journal.pntd.0011654
work_keys_str_mv AT renyuting extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT tianhongpan extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT xujiale extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT liumanqing extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT caikun extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT chenshuliang extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT nixuebing extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT liyirong extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT houwei extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022
AT chenliangjun extensivegeneticdiversityofseverefeverwiththrombocytopeniasyndromeviruscirculatinginhubeiprovincechina20182022