UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology

UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of...

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Autores principales: Price, Meghan J., Nguyen, Annee D., Byemerwa, Jovita K., Flowers, Jasmine, Baëta, César D., Goodwin, C. Rory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538703/
https://www.ncbi.nlm.nih.gov/pubmed/37769033
http://dx.doi.org/10.18632/oncotarget.28514
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author Price, Meghan J.
Nguyen, Annee D.
Byemerwa, Jovita K.
Flowers, Jasmine
Baëta, César D.
Goodwin, C. Rory
author_facet Price, Meghan J.
Nguyen, Annee D.
Byemerwa, Jovita K.
Flowers, Jasmine
Baëta, César D.
Goodwin, C. Rory
author_sort Price, Meghan J.
collection PubMed
description UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology.
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spelling pubmed-105387032023-09-29 UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology Price, Meghan J. Nguyen, Annee D. Byemerwa, Jovita K. Flowers, Jasmine Baëta, César D. Goodwin, C. Rory Oncotarget Review UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology. Impact Journals LLC 2023-09-28 /pmc/articles/PMC10538703/ /pubmed/37769033 http://dx.doi.org/10.18632/oncotarget.28514 Text en Copyright: © 2023 Price et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Price, Meghan J.
Nguyen, Annee D.
Byemerwa, Jovita K.
Flowers, Jasmine
Baëta, César D.
Goodwin, C. Rory
UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology
title UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology
title_full UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology
title_fullStr UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology
title_full_unstemmed UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology
title_short UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology
title_sort udp-glucose dehydrogenase (ugdh) in clinical oncology and cancer biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538703/
https://www.ncbi.nlm.nih.gov/pubmed/37769033
http://dx.doi.org/10.18632/oncotarget.28514
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