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Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements

PURPOSE: To compare glaucomatous from non-glaucomatous optic atrophy using optical coherence tomography (OCT) based on the measurement values of Bruch’s membrane opening minimum rim width (BMO-MRW), which is a difficult task otherwise due to their varied course of disease progression, treatment prot...

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Autores principales: Gosalia, Hirika, Kumar, Karthik M, Karan, A K, Saravanan, Veerappan R, Shah, Virna M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538806/
https://www.ncbi.nlm.nih.gov/pubmed/37530273
http://dx.doi.org/10.4103/IJO.IJO_3171_22
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author Gosalia, Hirika
Kumar, Karthik M
Karan, A K
Saravanan, Veerappan R
Shah, Virna M
author_facet Gosalia, Hirika
Kumar, Karthik M
Karan, A K
Saravanan, Veerappan R
Shah, Virna M
author_sort Gosalia, Hirika
collection PubMed
description PURPOSE: To compare glaucomatous from non-glaucomatous optic atrophy using optical coherence tomography (OCT) based on the measurement values of Bruch’s membrane opening minimum rim width (BMO-MRW), which is a difficult task otherwise due to their varied course of disease progression, treatment protocols, and systemic association to visual impairment. METHODS: This study was conducted in 40 eyes, comprising 20 eyes with non-glaucomatous optic neuropathy (NGON) and 20 eyes with glaucomatous optic neuropathy (GON). All patients underwent a complete ophthalmic examination followed by an OCT optic disc scan to calculate the measurement of BMO-MRW. RESULTS: The 5-fold cross-validated area under the curve for GON versus NGON from logistic regression models was 0.95 (95% confidence interval [CI]: 0.86–1.00) using BMO-MRW values from all sectors. The results revealed that the measurements were significantly lesser in GON than in NGON patients. CONCLUSION: Hence, OCT-based BMO-MRW values could be used as an additional test to compare glaucomatous with non-glaucomatous optic neuropathy patients, especially in cases of high clinical suspicion.
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spelling pubmed-105388062023-09-29 Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements Gosalia, Hirika Kumar, Karthik M Karan, A K Saravanan, Veerappan R Shah, Virna M Indian J Ophthalmol Original Article PURPOSE: To compare glaucomatous from non-glaucomatous optic atrophy using optical coherence tomography (OCT) based on the measurement values of Bruch’s membrane opening minimum rim width (BMO-MRW), which is a difficult task otherwise due to their varied course of disease progression, treatment protocols, and systemic association to visual impairment. METHODS: This study was conducted in 40 eyes, comprising 20 eyes with non-glaucomatous optic neuropathy (NGON) and 20 eyes with glaucomatous optic neuropathy (GON). All patients underwent a complete ophthalmic examination followed by an OCT optic disc scan to calculate the measurement of BMO-MRW. RESULTS: The 5-fold cross-validated area under the curve for GON versus NGON from logistic regression models was 0.95 (95% confidence interval [CI]: 0.86–1.00) using BMO-MRW values from all sectors. The results revealed that the measurements were significantly lesser in GON than in NGON patients. CONCLUSION: Hence, OCT-based BMO-MRW values could be used as an additional test to compare glaucomatous with non-glaucomatous optic neuropathy patients, especially in cases of high clinical suspicion. Wolters Kluwer - Medknow 2023-08 2023-08-01 /pmc/articles/PMC10538806/ /pubmed/37530273 http://dx.doi.org/10.4103/IJO.IJO_3171_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gosalia, Hirika
Kumar, Karthik M
Karan, A K
Saravanan, Veerappan R
Shah, Virna M
Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements
title Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements
title_full Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements
title_fullStr Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements
title_full_unstemmed Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements
title_short Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch’s membrane opening minimum rim width optical coherence tomography measurements
title_sort comparison of glaucomatous from non-glaucomatous optic neuropathy using bruch’s membrane opening minimum rim width optical coherence tomography measurements
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538806/
https://www.ncbi.nlm.nih.gov/pubmed/37530273
http://dx.doi.org/10.4103/IJO.IJO_3171_22
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