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Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel

Milletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degradation. Therefore, in this, study, a green hydrodistillation t...

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Autores principales: Bhagyashree Devidas, Tipare, Patil, Sandip, Sharma, Minaxi, Ali, Nemat, Parvez, Mohammad Khalid, Al-Dosari, Mohammed S., Liu, Sixi, Inbaraj, Baskaran Stephen, Bains, Aarti, Wen, Feiqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538964/
https://www.ncbi.nlm.nih.gov/pubmed/37780989
http://dx.doi.org/10.3389/fchem.2023.1260165
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author Bhagyashree Devidas, Tipare
Patil, Sandip
Sharma, Minaxi
Ali, Nemat
Parvez, Mohammad Khalid
Al-Dosari, Mohammed S.
Liu, Sixi
Inbaraj, Baskaran Stephen
Bains, Aarti
Wen, Feiqiu
author_facet Bhagyashree Devidas, Tipare
Patil, Sandip
Sharma, Minaxi
Ali, Nemat
Parvez, Mohammad Khalid
Al-Dosari, Mohammed S.
Liu, Sixi
Inbaraj, Baskaran Stephen
Bains, Aarti
Wen, Feiqiu
author_sort Bhagyashree Devidas, Tipare
collection PubMed
description Milletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degradation. Therefore, in this, study, a green hydrodistillation technology was used to extract M. pinnata oil and N. jatamansi root for the further application in development of pectin crosslinked carboxymethyl cellulose/guar-gum nano hydrogel. Both oil and extract revealed the presence of spirojatamol and hexadecanoic acid methyl ester. Varied concentrations (w/w) of cross-linker and gelling agent were used to formulate oil emulsion extract gel (OEEG1, OEG1, OEEG2, OEG2, OEEG3, OEG3, OEEG4, OEG4, OEEG5, OEG5), in which OEEG2 and OEG2 were found to be stable. The hydrogel displayed an average droplet size of 186.7 nm and a zeta potential of −20.5 mV. Endo and exothermic peaks and the key functional groups including hydroxyl, amide II, and amide III groups confirmed thermal stability and molecular structure. The smooth surface confirmed structural uniformity. Bactericidal activity against both Gram-positive (25.41 ± 0.09 mm) and Gram-negative (27.25 ± 0.01 mm) bacteria and anti-inflammatory activity (49.25%–83.47%) makes nanohydrogel a potential option for treating various infections caused by pathogenic microorganisms. In conclusion, the use of green hydrodistillation technology can be used to extract the bioactive compounds that can be used in formulation of biocompatible and hydrophobic nanohydrogels. Their ability to absorb target-specific drugs makes them a potential option for treating various infections caused by pathogenic microorganisms.
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spelling pubmed-105389642023-09-29 Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel Bhagyashree Devidas, Tipare Patil, Sandip Sharma, Minaxi Ali, Nemat Parvez, Mohammad Khalid Al-Dosari, Mohammed S. Liu, Sixi Inbaraj, Baskaran Stephen Bains, Aarti Wen, Feiqiu Front Chem Chemistry Milletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degradation. Therefore, in this, study, a green hydrodistillation technology was used to extract M. pinnata oil and N. jatamansi root for the further application in development of pectin crosslinked carboxymethyl cellulose/guar-gum nano hydrogel. Both oil and extract revealed the presence of spirojatamol and hexadecanoic acid methyl ester. Varied concentrations (w/w) of cross-linker and gelling agent were used to formulate oil emulsion extract gel (OEEG1, OEG1, OEEG2, OEG2, OEEG3, OEG3, OEEG4, OEG4, OEEG5, OEG5), in which OEEG2 and OEG2 were found to be stable. The hydrogel displayed an average droplet size of 186.7 nm and a zeta potential of −20.5 mV. Endo and exothermic peaks and the key functional groups including hydroxyl, amide II, and amide III groups confirmed thermal stability and molecular structure. The smooth surface confirmed structural uniformity. Bactericidal activity against both Gram-positive (25.41 ± 0.09 mm) and Gram-negative (27.25 ± 0.01 mm) bacteria and anti-inflammatory activity (49.25%–83.47%) makes nanohydrogel a potential option for treating various infections caused by pathogenic microorganisms. In conclusion, the use of green hydrodistillation technology can be used to extract the bioactive compounds that can be used in formulation of biocompatible and hydrophobic nanohydrogels. Their ability to absorb target-specific drugs makes them a potential option for treating various infections caused by pathogenic microorganisms. Frontiers Media S.A. 2023-09-14 /pmc/articles/PMC10538964/ /pubmed/37780989 http://dx.doi.org/10.3389/fchem.2023.1260165 Text en Copyright © 2023 Bhagyashree Devidas, Patil, Sharma, Ali, Parvez, Al-Dosari, Liu, Inbaraj, Bains and Wen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Bhagyashree Devidas, Tipare
Patil, Sandip
Sharma, Minaxi
Ali, Nemat
Parvez, Mohammad Khalid
Al-Dosari, Mohammed S.
Liu, Sixi
Inbaraj, Baskaran Stephen
Bains, Aarti
Wen, Feiqiu
Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
title Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
title_full Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
title_fullStr Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
title_full_unstemmed Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
title_short Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
title_sort green extraction of milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538964/
https://www.ncbi.nlm.nih.gov/pubmed/37780989
http://dx.doi.org/10.3389/fchem.2023.1260165
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