Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report

We herein present a case involving an 86-year-old man with abdominal aortic aneurysm complicated by symptomatic disseminated intravascular coagulation (DIC). The patient received preoperative treatment for DIC using recombinant human soluble thrombomodulin (rTM) followed by open surgical repair of t...

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Autores principales: Yamamoto, Yohei, Uchiyama, Hidetoshi, Oonuki, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539116/
https://www.ncbi.nlm.nih.gov/pubmed/37779649
http://dx.doi.org/10.3400/avd.cr.23-00009
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author Yamamoto, Yohei
Uchiyama, Hidetoshi
Oonuki, Masahiro
author_facet Yamamoto, Yohei
Uchiyama, Hidetoshi
Oonuki, Masahiro
author_sort Yamamoto, Yohei
collection PubMed
description We herein present a case involving an 86-year-old man with abdominal aortic aneurysm complicated by symptomatic disseminated intravascular coagulation (DIC). The patient received preoperative treatment for DIC using recombinant human soluble thrombomodulin (rTM) followed by open surgical repair of the aneurysm. The patient’s coagulopathy cleared quickly after the start of rTM, and the intraoperative and postoperative course went smoothly. The patient was followed without anticoagulant medication, and there was no recurrence of DIC during 14 months of follow-up. The preoperative administration of rTM can be a useful choice to assist safe treatment of aortic aneurysm complicated by aneurysm-related DIC.
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spelling pubmed-105391162023-09-30 Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report Yamamoto, Yohei Uchiyama, Hidetoshi Oonuki, Masahiro Ann Vasc Dis Case Report We herein present a case involving an 86-year-old man with abdominal aortic aneurysm complicated by symptomatic disseminated intravascular coagulation (DIC). The patient received preoperative treatment for DIC using recombinant human soluble thrombomodulin (rTM) followed by open surgical repair of the aneurysm. The patient’s coagulopathy cleared quickly after the start of rTM, and the intraoperative and postoperative course went smoothly. The patient was followed without anticoagulant medication, and there was no recurrence of DIC during 14 months of follow-up. The preoperative administration of rTM can be a useful choice to assist safe treatment of aortic aneurysm complicated by aneurysm-related DIC. Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2023-09-25 /pmc/articles/PMC10539116/ /pubmed/37779649 http://dx.doi.org/10.3400/avd.cr.23-00009 Text en © 2023 The Editorial Committee of Annals of Vascular Diseases. https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
spellingShingle Case Report
Yamamoto, Yohei
Uchiyama, Hidetoshi
Oonuki, Masahiro
Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report
title Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report
title_full Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report
title_fullStr Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report
title_full_unstemmed Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report
title_short Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report
title_sort use of recombinant human soluble thrombomodulin in a patient with disseminated intravascular coagulation associated with abdominal aortic aneurysm: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539116/
https://www.ncbi.nlm.nih.gov/pubmed/37779649
http://dx.doi.org/10.3400/avd.cr.23-00009
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